Background. The potential role of VEGF in osteosarcoma has been evaluated in several studies. The majority of them included heterogeneous and limited series of patients, giving conflicting results. The aim of presented study is to evaluate the prognostic role of VEGF-A in biopsy samples of clinically homogeneous group of osteosarcoma patients with at least 5 years of follow up. Materials and Methods. VEGF-A was assessed immunohistochemically in the pre-treatment biopsy samples of 91 patients (mean age 14 years; range, 4-23 years) with primary, high-grade, non-metastatic osteosarcoma localized in extremities. The survival of each patient was assessed after at least 5-year follow-up period. Results. VEGF-A over 50% of positive tumor cells was observed in 39% of cases and was linked to patients age below 14-year old (P = 0.025) and tumor size more than 8 cm (P = 0.054). VEGF-A was associated with a significantly decreased both overall survival (P = 0.006) and progression-free survival (P = 0.011). In the Cox proportional hazard model it was confirmed that VEGF-A expression in the biopsy samples was an independent prognostic factor of unfavorable survival in osteosarcoma (HR 2.51; 95% CI: 1.12-5.66). Conclusion. The expression of VEGF-A in the biopsy sample is the potential marker for predicting the course and outcome of osteosarcoma. Pediatr Blood Cancer 2011;57:63-68. (C) 2011 Wiley-Liss, Inc.
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Nanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R ChinaNanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R China
Qu, Y.
Xu, J.
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Nanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R ChinaNanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R China
Xu, J.
Jiang, T.
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Nanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R ChinaNanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R China
Jiang, T.
Zhao, H.
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Nanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R ChinaNanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R China
Zhao, H.
Gao, Y.
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Nanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R ChinaNanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R China
Gao, Y.
Zheng, C.
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Nanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R ChinaNanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R China
Zheng, C.
Shi, X.
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Nanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R ChinaNanjing Univ Tradit Chinese Med, Dept Orthopaed, Changzhou Tradit Chinese Med Hosp, Changzhou, Peoples R China
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Second Mil Med Univ, Changzheng Hosp, Dept Orthoped, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Dept Orthoped, Shanghai 200433, Peoples R China
Qu, Jin-tao
Wang, Mei
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Second Mil Med Univ, Changzheng Hosp, Dept Orthoped, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Dept Orthoped, Shanghai 200433, Peoples R China
Wang, Mei
He, Hai-long
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Second Mil Med Univ, Changzheng Hosp, Dept Orthoped, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Dept Orthoped, Shanghai 200433, Peoples R China
He, Hai-long
Tang, Yu
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Second Mil Med Univ, Changzheng Hosp, Dept Orthoped, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Changzheng Hosp, Dept Orthoped, Shanghai 200433, Peoples R China
Tang, Yu
Ye, Xiao-jian
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