Comparison of COBE® Spectra™ software version 4.7 PBSC and version 6.0 auto PBSC™ program

被引:0
|
作者
Wilke, R
Brettell, M
Prince, HM
Wolf, M
McKenna, R
Serpell, E
Molloy, M
Stevens, H
Quinn, M
Gates, P
Chapple, P
机构
[1] Peter MacCallum Canc Inst, Div Haematol & Med Oncol, Autologous Blood & Marrow Transplant Serv, Melbourne, Vic 3000, Australia
[2] Peter MacCallum Canc Inst, Div Haematol & Med Oncol, Ian Cooper Cell Seperator Unit, Melbourne, Vic 3000, Australia
关键词
stem cells; apheresis; autologous transplantation;
D O I
10.1002/(SICI)1098-1101(1999)14:1<26::AID-JCA5>3.0.CO;2-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Until recently, the collection of peripheral blood progenitor cells (PBPC) has been semi-automated by using the COPE(R) Spectra(TM), with the operator manually maintaining the position of the white cells being collected. The COPE(R) Spectra(TM) Version 6.0 apheresis device offers the user an automated program for the collection of PBPC. In this study, we compared the new software Version 6.0 to that of Version 4.7. Patients (n = 46) undergoing PBPC collection were allocated to cell processing with either Version 4.7 (n = 24) or Version 6.0 (n = 22). The CD34+ cell count, mononuclear cell (MNC) count, white cell count (WCC), hemoglobin (Hb), and platelet content in the autograft product by using the two versions were compared. We divided the analysis into three subsets according to peripheral blood (PB) CD34 content: <10x10(6)/L, 10-50x10(6)/L and >50x10(6)/L. Analysis of the three subsets showed no statistical difference between results obtained when the starting PB CD34+ cell count was 10-50x106/L (P=0.08) or >50 x10(6)/L (P=0.4065). At lower starting PB CD34+ cell counts of <10x106/L, Version 4.7 was superior (P=0.0167). However, autograft platelet contamination of the autograft was significantly higher using Version 4.7 (P=<0.0001). (C) 1999 Wiley-Liss, Inc.
引用
收藏
页码:26 / 30
页数:5
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