Notch1 and T-cell development: insights from conditional knockout mice

被引：0
|
作者：
MacDonald, HR [1 ]
Wilson, A [1 ]
Radtke, F [1 ]
机构：
[1] Univ Lausanne, Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Epalinges, Switzerland
来源：
TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Notch proteins influence cell-fate decisions in many developmental systems, Gain-of-function studies have suggested a crucial role for Notch 1 signaling at several stages during lymphocyte development, including the B/T, alpha beta/gamma delta and CD4/CD8 lineage choices. Here, we critically re-evaluate these conclusions in the light of recent studies that describe inducible and tissue-specific targeting of the Notch 1 gene.
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页码：155 / 160
页数：6
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