EXTRACORPOREAL SHOCK WAVES INDUCE OSTEOGENIC DIFFERENTIATION OF HUMAN BONE-MARROW STROMAL CELLS

被引：0
|
作者：
Notarnicola, A. [1 ]
Vicenti, G. [1 ]
Maccagnano, G. [1 ]
Silvestris, F. [2 ]
Cafforio, P. [2 ]
Moretti, B. [1 ]
机构：
[1] Univ Study Bari Aldo Moro, Fac Med & Surg, Dept Med Sci Basis Neurosci & Organs Sense, Course Motor & Sports Sci, Bari, Italy
[2] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Bari, Italy
来源：
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2016年 / 30卷 / 04期
关键词：
shock waves; stem cell; differentiation; bone;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effects of treatment with shock waves (SW) on osteoblastic cells have already been described. Furthermore, the effects of treatment with SW are also determined by the contextual stimulation of other cell lines, in particular of mesenchymal cells. This is the first experimental study of stimulation of a human mesenchymal stem cell line, taken from bone marrow, using SW (electromagnetic device), with two energy levels. The results showed a significant increase in expression of the main osteoblastic differentiation genes: BMP2, alkaline phosphatase, osteocalcin, COL1A1, RUNX2. The monitoring within 96 hours demonstrated a progressive increase of cell adhesion and an intense cell proliferation at 48 h. The differentiation response and proliferation of stem cells after treatment with SW shows that this therapy is an effective method of regenerative medicine.
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页码：139 / 144
页数：6
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