Expression of E-cadherin and β-catenin in primary and peritoneal metastatic ovarian carcinoma

被引:5
|
作者
Fujioka, T
Takebayashi, Y
Kihana, T
Kusanagi, Y
Hamada, K
Ochi, H
Uchida, T
Fukumoto, M
Ito, M
机构
[1] Tohoku Univ, Inst Dev Aging & Canc, Dept Pathol, Aoba Ku, Sendai, Miyagi 9808575, Japan
[2] Ehime Univ, Sch Med, Dept Obstet & Gynecol, Shigenobu, Ehime 7910295, Japan
关键词
beta-catenin; E-cadherin; ovarian carcinoma; peritoneal metastasis;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Protein expression levels of E-cadherin and beta -catenin were examined in 39 primary and 10 metastatic ovarian carcinoma to elucidate the role of these molecules in the extension of ovarian carcinoma by immunohistochemistry. Twenty-two of 39 (56%) ovarian carcinomas were preserved type and 17 of 39 (44%) were reduced type of E-cadherin. In contrast, 36 of 39 (92%) ovarian carcinomas were preserved type and 3 of 39 (8%) were reduced type of beta -catenin. E-cadherin expression in well-differentiated carcinoma was higher than that in moderately/poorly-differentiated carcinoma (p<0.05). Interestingly, 6 of 10 (60%) peritoneal metastatic lesions resulted in the reduced expression of E-cadherin compared with primary lesions. In contrast, only 2 of 10 (20%) metastatic lesions showed reduced expression of <beta>-catenin compared with primary lesions. Mutation of exon 3 of beta -catenin gene was rare (3%, 1/39) in carcinoma. These results suggested that the cell adhesion molecule E-cadherin might play an important role in the formation of peritoneal metastasis. In contrast, beta -catenin is not a good indicator of metastasis in human ovarian carcinoma.
引用
收藏
页码:249 / 255
页数:7
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