Cedrol Induces Apoptosis of Oral Squamous Cell Carcinoma Cell

被引:0
|
作者
Yu, Di [1 ]
Yan, Junjie [2 ]
机构
[1] Wenzhou Med Univ, Dept Stomatol, Affiliated Hosp 3, Wenzhou 325206, Zhejiang, Peoples R China
[2] Lishui Univ, Lishui Dent Hosp, Dept Stomatol, Dent Hosp, 58 Wanfeng Dong Lu, Lishui 323000, Zhejiang, Peoples R China
关键词
Apoptosis; Cedrol; OSCC; PI3K/Akt/mTOR pathway; ROS; Viability;
D O I
10.37290/ctnr2641-452X.20:328-333
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Oral squamous cell carcinoma is a common oral cancer with high morbidity and mortality. There is an urgent need to search for new therapeutic targets and better drugs for the treatment of this disease. In the present study, we have explored the effect of cedrol, a sesquiterpene alcohol with multitude of anticancerous properties, on the progression of oral squamous cell carcinoma. Our results show cedrol to induce generation of reactive oxygen species, apoptosis, and reduction in cell viability of oral squamous cell carcinoma cells. This opens the possibility of cedrol serving as a potential therapeutic agent.
引用
收藏
页码:328 / 333
页数:6
相关论文
共 50 条
  • [1] α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell
    Kwak, Hyun-Ho
    Kim, In-Ryoung
    Kim, Hye-Jin
    Park, Bong-Soo
    Yu, Su-Bin
    [J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2016, 2016
  • [2] Erianin Induces Apoptosis and Autophagy in Oral Squamous Cell Carcinoma Cells
    Chen, Yi-Tzu
    Hsieh, Ming-Ju
    Chen, Pei-Ni
    Weng, Chia-Jui
    Yang, Shun-Fa
    Lin, Chiao-Wen
    [J]. AMERICAN JOURNAL OF CHINESE MEDICINE, 2020, 48 (01): : 183 - 200
  • [3] Apoptosis in oral squamous cell carcinoma
    Coutinho Camillo, C. Malheiros
    Nagano, C. Pidorodeski
    Lourengo, S. V.
    Fregnani, J. H.
    Carvalho, A. Lopes
    Kowalski, L. P.
    Soares, F. A.
    [J]. EJC SUPPLEMENTS, 2008, 6 (09): : 146 - 147
  • [4] LINC00961 suppresses cell proliferation and induces cell apoptosis in oral squamous cell carcinoma
    Pan, L-N
    Sun, Y-R
    [J]. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 23 (08) : 3358 - 3365
  • [5] Trichostatin A induces apoptosis in oral squamous cell carcinoma cell lines independent of hyperacetylation of histones
    Jang, Boonsil
    Kim, Lee-Han
    Lee, Seung-Youp
    Lee, Kyung-Eun
    Shin, Ji-Ae
    Cho, Sung-Dae
    Cho, Sung-Dae
    [J]. JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2018, 14 : S576 - S582
  • [6] Surfactin induces autophagy, apoptosis, and cell cycle arrest in human oral squamous cell carcinoma
    Vo, Thi Thuy Tien
    Wee, Yinshen
    Cheng, Hsin-Chung
    Wu, Ching-Zong
    Chen, Yuh-Lien
    Tuan, Vo Phuoc
    Liu, Ju-Fang
    Lin, Wei-Ning
    Lee, I-Ta
    [J]. ORAL DISEASES, 2023, 29 (02) : 528 - 541
  • [7] Ilimaquinone Induces Apoptosis and Autophagy in Human Oral Squamous Cell Carcinoma Cells
    Lin, Cheng-Wen
    Bai, Li-Yuan
    Su, Jui-Hsin
    Chiu, Chang-Fang
    Lin, Wei-Yu
    Huang, Wei-Ting
    Shih, Ming-Cheng
    Huang, Yu-Ting
    Hu, Jing-Lan
    Weng, Jing-Ru
    [J]. BIOMEDICINES, 2020, 8 (09)
  • [8] Identification of Portimine B, a New Cell Permeable Spiroimine That Induces Apoptosis in Oral Squamous Cell Carcinoma
    Fribley, Andrew M.
    Xi, Yue
    Makris, Christina
    Alves-de-Souza, Catharina
    York, Robert
    Tomas, Carmelo
    Wright, Jeffrey L. C.
    Strangman, Wendy K.
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2019, 10 (02): : 175 - 179
  • [9] Gambogenic acid induces apoptosis via upregulation of Noxa in oral squamous cell carcinoma
    Cheng, Xinran
    Feng, Mengyuan
    Zhang, Anjie
    Guo, Jian
    Gong, Yunlai
    Hu, Xiaohui
    Han, Quanbin
    Li, Shengbao
    Yu, Xianjun
    [J]. CHINESE JOURNAL OF NATURAL MEDICINES, 2024, 22 (07) : 632 - 642
  • [10] Heparin Induces Apoptosis through Suppression of AKt in Oral Squamous Cell Carcinoma Cells
    Ueda, Kohei
    Inoue, Shuichi
    Zhang, Ye
    Kutsuna, Tomohiko
    Inoue, Sayaka
    Noto, Kumiko
    Arai, Naoya
    Noguchi, Makoto
    [J]. ANTICANCER RESEARCH, 2009, 29 (04) : 1079 - 1088