An Electrospun Scaffold Loaded with an Enteromorpha Polysaccharide for Accelerated Wound Healing in Diabetic Mice

被引:10
|
作者
Guo, Lili [1 ,2 ]
Guan, Na [1 ]
Miao, Wenjun [1 ]
Zhao, Wenwen [3 ]
Li, Qiu [1 ]
机构
[1] Qingdao Agr Univ, Agr Biopharmaceut Lab, Qingdao 266109, Peoples R China
[2] South China Agr Univ, Coll Vet Med, Guangzhou 510642, Peoples R China
[3] Qingdao Univ, Sch Basic Med, 308 Ningxia Rd, Qingdao 266021, Peoples R China
基金
中国国家自然科学基金;
关键词
enteromorpha polysaccharide; anti-inflammatory; diabetic wound healing; NANOFIBERS;
D O I
10.3390/md20020095
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The design and development of innovative multifunctional wound dressing materials in engineered biomaterials is essential for promoting tissue repair. In this study, nanofibrous wound dressing materials loaded with anti-inflammatory ingredients were manufactured by a promising electrospinning strategy, and their capability for treating diabetic wounds was also investigated. A scaffold blend consisting of an Enteromorpha polysaccharide and polyvinyl alcohol (PVA) was fabricated. The in vitro and in vivo studies confirmed the efficacy of PVA/EPP1 fiber. We found that PVA/EPP1 fiber accelerated the repair of a full-thickness skin wound in diabetic mice. The results suggest that this scaffold could effectively shorten the wound healing time by inhibiting inflammatory activity, which makes it a promising candidate for the treatment of hard-to-heal wounds caused by diabetes.
引用
收藏
页数:10
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