Is intractable epilepsy a tauopathy?

被引：21

作者：

Xi, Zhi-Qin ^{[1
]}

Wang, Xue-Feng ^{[1
]}

Shu, Xiao-Fang ^{[2
]}

Chen, Guo-Jun ^{[1
]}

Xiao, Fei ^{[1
]}

Sun, Ji-Jun ^{[1
]}

Zhu, Xi ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China

[2] Cent Hosp Mianyang City, Dept Obstet & Gynaecol, Mianyang City, Sichuan Prov, Peoples R China

来源：

MEDICAL HYPOTHESES | 2011年 / 76卷 / 06期

关键词：

TEMPORAL-LOBE EPILEPSY; MICROTUBULE-ASSOCIATED PROTEINS; INCREASED TAU-PHOSPHORYLATION; ALZHEIMERS-DISEASE; CORTICAL DYSPLASIA; PARKINSON-DISEASE; RAT NEOCORTEX; IN-VITRO; SEIZURES; HIPPOCAMPUS;

D O I：

10.1016/j.mehy.2011.03.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tau exists in neuronal axons and glial cells of the central nervous system and contributes to the maintenance of the unique cell morphology. It functions in axon elongation, cell polarity formation and microtubule stabilization. Aggregates and hyper-phosphorylated tau proteins are classical components of neurofibrillary lesions in numerous neurodegenerative disorders, which are called "tauopathies". Recent studies have demonstrated that tau-associated genes and proteins and tau phosphorylation were abnormal in intractable epilepsy. Therefore, the discovery of the dysfunctional tau in intractable epilepsy opens a new window in the study of central tauopathy. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：897 / 900

页数：4

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