Formulation, Development, Evaluation and Solubility Enhancement of Lercanidipine Hydrochloride by Solid Dispersion Techniques

被引:0
|
作者
Mankar, S. D. [1 ]
Rachh, Punit R. [1 ]
机构
[1] Bhagwant Univ, Dept Pharmaceut Sci, Ajmer, Rajasthan, India
关键词
Solid dispersion; dissolution; solubility; dispersion; POLYETHYLENE-GLYCOL; 6000; PHYSICOCHEMICAL CHARACTERIZATION; IN-VITRO; DISSOLUTION; PEG; BIOAVAILABILITY; RELEASE;
D O I
10.9734/JPRI/2021/v33i53B33697
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Solid dispersions (SDs) are the dispersion of hydrophobic drugs in an inert hydrophilic carrier. SDs are prepared to improve the dissolution properties and bioavailability of slightly water-soluble drug molecules by dispersing them into an inert hydrophilic carrier. Aims and Objective: Evaluate the dissolution and solubility of Solid Dispersion of Lercanidipine Hydrochloride (LER). Materials and Methods: To study the effect of polymer, dissolution and solubility studies were carried out. Solid state characterizations of prepared solid dispersions were performed by differential scanning calorimetry (DSC).Drug- carrier interactions were studied by FT-IR spectroscopy, whereas X-ray diffraction of powder was done to demonstrate the crystal structure of the dispersions. Results: The prepared solid dispersion exhibited 94% drug release at 30 minutes which is higher than both LER pure and LER MKT. Better dissolution characteristic of solid dispersion was confirmed by 9.86 min MDT and 63.12% DE30 which is higher than that of LER MKT (13.64 MDT, 46.92 % DE30) Solid state characterization revealed that enhancement of dissolution is the result of conversion of crystalline form of LER to less crystalline and/or amorphous form. Conclusion: Solid dispersion of LER can successfully be prepared with the PEG6000 in the ratio of 1:6 using solvent evaporation technique. It is a successful and easy approach for the increase in onset of action of drug after administration and facilitates treatment of cardiovascular diseases.
引用
收藏
页码:195 / 213
页数:19
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