Efficacy and safety of generic amphotericin B in experimental pulmonary aspergillosis

被引：11
|
作者：
Petraitis, V
Petraitiene, R
Lin, PX
Calis, K
Kelaher, AM
Muray, HA
Mya-San, C
Mickiene, D
Bacher, J
Walsh, TJ
机构：
[1] NCI, Pediat Oncol Branch, Immunocompromised Host Sect, CRC, Bethesda, MD 20892 USA
[2] NIH, Surg Serv, Vet Resources Program, Off Res Serv, Bethesda, MD USA
[3] Warren Grant Magnuson Clin Ctr, Dept Pharm, Bethesda, MD USA
[4] SAIC Frederick Inc, Frederick, MD USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 04期
关键词：
D O I：
10.1128/AAC.49.4.1642-1645.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The recent shortage of the brand name drug Fungizone has necessitated a change to generic formulations of amphotericin B deoxycholate. Clinical trials cannot be conducted in a timely manner to provide data on the safety and efficacy of these formulations. We therefore compared generic amphotericin B and Fungizone for activity and safety in the treatment of experimental invasive pulmonary aspergillosis (IPA) in persistently neutropenic rabbits. Fungizone and generic amphotericin B are similar in efficacy, pharmacokinetics, and safety in the treatment of experimental IPA.
引用
收藏
页码：1642 / 1645
页数：4
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