Sputnik V Effectiveness against Hospitalization with COVID-19 during Omicron Dominance

被引：10

作者：

Shkoda, Andrey S. ^{[1
]}

Gushchin, Vladimir A. ^{[2
,3
]}

Ogarkova, Darya A. ^{[2
]}

Stavitskaya, Svetlana, V ^{[1
]}

Orlova, Olga E. ^{[1
]}

Kuznetsova, Nadezhda A. ^{[2
]}

Keruntu, Elena N. ^{[1
]}

Pochtovyi, Andrei A. ^{[2
,3
]}

Pukhov, Alexander, V ^{[1
]}

Kleymenov, Denis A. ^{[2
]}

Krzhanovsky, Vasyli G. ^{[1
]}

Vasina, Daria V. ^{[2
]}

Shkuratova, Nataliya, V ^{[1
]}

Shidlovskaya, Elena, V ^{[2
]}

Gorbunov, Alexey L. ^{[1
]}

Kustova, Daria D. ^{[2
,3
]}

Mazurina, Evgeniya A. ^{[1
]}

Kozlova, Sofya R. ^{[2
]}

Soboleva, Alexandra, V ^{[1
]}

Grigoriev, Igor, V ^{[2
]}

Pankratyeva, Lyudmila L. ^{[1
]}

Odintsova, Alina S. ^{[2
]}

Belyaeva, Elizaveta D. ^{[2
,3
]}

Bessonova, Arina A. ^{[2
]}

Vasilchenko, Lyudmila A. ^{[2
]}

Lupu, Igor P. ^{[2
]}

Adgamov, Ruslan R. ^{[2
]}

Tkachuk, Artem P. ^{[2
]}

Tokarskaya, Elizaveta A. ^{[2
]}

Logunov, Denis Y. ^{[2
]}

Gintsburg, Alexander L. ^{[2
,4
]}

机构：

[1] City Clin Hosp 67, Moscow City Dept, Moscow 123423, Russia

[2] Minist Hlth Russian Federat, Fed State Budget Inst, Natl Res Ctr Epidemiol & Microbiol, Moscow 123098, Russia

[3] Lomonosov Moscow State Univ, Biol Fac, Dept Virol, Moscow 119991, Russia

[4] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Minist Hlth Russian Federat, Dept Infectiol & Virol,Fed State Autonomous Educ, Moscow 119435, Russia

来源：

VACCINES | 2022年 / 10卷 / 06期

关键词：

COVID-19; SARS-CoV-2; vaccine; Sputnik V; Sputnik Light; VOC; Omicron; vaccine effectiveness; VACCINE;

D O I：

10.3390/vaccines10060938

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mass vaccination campaigns against COVID-19 affected more than 90% of the population in most developed countries. The new epidemiologic wave of COVID-19 has been ongoing since the end of 2021. It is caused by a virus variant B.1.1.529, also known as "Omicron" and its descendants. The effectiveness of major vaccines against Omicron is not known. The purpose of this study is to evaluate the efficacy of the Sputnik V vaccine. The main goal is to assess its protection against hospitalization in the period of Omicron dominance. We conducted our study based on a large clinical center in Moscow (Russia) where 1112 patients were included. We used the case-population method to perform the calculations. The data we obtained indicate that the Omicron variant causes at least 90% of infections in the studied cohort. The effectiveness of protection against hospitalization with COVID-19 in our study was 85.9% (95% CI 83.0-88.0%) for those who received more than one dose. It was 87.6% (95% CI 85.4-89.5%) and 97.0% (95% CI 95.9-97.8%) for those who received more than two or three doses. The effectiveness in cases of more severe forms was higher than for less severe ones. Thus, present study indicates the high protective efficacy of vaccination against hospitalization with COVID-19 in case of Omicron lineage.

引用

页数：15

共 50 条

[1] COVID-19 Vaccine Effectiveness Against Omicron Infection and Hospitalization
Piche-Renaud, Pierre-Philippe
Swayze, Sarah B.
Buchan, Sarah
Wilson, Sarah B.
Austin, Peter Z.
Morris, Shaun
Nasreen, Sharifa E.
Schwartz, Kevin M.
Tadrous, Mina
Thampi, Nisha H.
Wilson, Kumanan E.
Kwong, Jeffrey
[J]. PEDIATRICS, 2023, 151 (04)
[2] Effectiveness of COVID-19 vaccines against Omicron variant
de Oliveira Campos, Daniel Melo
da Silva, Maria Karolaynne
Silva de Oliveira, Claudio Bruno
Fulco, Umberto Laino
Nobre Oliveira, Jonas Ivan
[J]. IMMUNOTHERAPY, 2022,
[3] Effectiveness of COVID-19 vaccines among children 6–11 years against hospitalization during Omicron predominance in Malaysia
Vivek Jason Jayaraj
Masliyana Husin
Jing Lian Suah
Peter Seah Keng Tok
Azahadi Omar
Sanjay Rampal
Sheamini Sivasampu
[J]. Scientific Reports, 14
[4] SAFETY AND EFFECTIVENESS OF COVID-19 SPUTNIK V VACCINE IN DIALYSIS PATIENTS
Rosa-Diez, Guillermo
Leiva, Maria Marina Papaginovic
Lombi, Fernando
Crucelegui, Maria Soledad
Martinez, Ricardo D.
Trimarchi, Hernan
Schiavelli, Ruben
Grizzo, Mercedes
Rano, Miguel
Heguilen, Ricardo M.
Jones, Rocio A.
Paganti, Luciana Gonzalez
Ferrrari, Matias
Kjohede, Victoria
Zingoni, Paula
Geffner, Jorge R.
Ferrante, Daniel
De Quiros, Fernan Gonzalez Bernaldo
Pagotto, Vanina
[J]. MEDICINA-BUENOS AIRES, 2022, 82 (05) : 631 - 640
[5] Sputnik Light and Sputnik V Vaccination Is Effective at Protecting Medical Personnel from COVID-19 during the Period of Delta Variant Dominance
Sukhikh, Gennady T.
Priputnevich, Tatiana, V
Ogarkova, Darya A.
Pochtovyi, Andrei A.
Kustova, Daria D.
Zlobin, Vladimir, I
Logunov, Denis Y.
Gushchin, Vladimir A.
Gintsburg, Alexander L.
[J]. VACCINES, 2022, 10 (11)
[6] Effectiveness of COVID-19 vaccines among children 6-11 years against hospitalization during Omicron predominance in Malaysia
Jayaraj, Vivek Jason
Husin, Masliyana
Suah, Jing Lian
Tok, Peter Seah Keng
Omar, Azahadi
Rampal, Sanjay
Sivasampu, Sheamini
[J]. SCIENTIFIC REPORTS, 2024, 14 (01)
[7] Effectiveness of Homologous and Heterologous Covid-19 Boosters against Omicron
Accorsi, Emma K.
Britton, Amadea
Shang, Nong
Fleming-Dutra, Katherine E.
Link-Gelles, Ruth
Smith, Zachary R.
Derado, Gordana
Miller, Joseph
Schrag, Stephanie J.
Verani, Jennifer R.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (25): : 2433 - 2435
[8] Risk of hospitalization and vaccine effectiveness among COVID-19 patients in the UAE during the Delta and Omicron outbreaks
Albreiki, Mohammed
Mousa, Mira
Azman, Syafiq Kamarul
Vurivi, Hema
Alhalwachi, Zainab
Alshehhi, Fatima
AlShamsi, Safiya
Marzouqi, Nada Al
Alawadi, Tayba
Alrand, Hussain
Oulhaj, Abderrahim
Fikri, Asma
Alsafar, Habiba
[J]. FRONTIERS IN IMMUNOLOGY, 2023, 14
[9] The Sputnik V Vaccine against COVID-19: A Promising Platform for Mass Vaccination
Israeli, Eitan
Shoenfeld, Yehuda
[J]. ISRAEL MEDICAL ASSOCIATION JOURNAL, 2022, 24 (02): : 71 - 73
[10] Duration of effectiveness of vaccination against COVID-19 caused by the omicron variant
Higdon, Melissa M.
Baidya, Anurima
Walter, Karoline K.
Patel, Minal K.
Issa, Hanane
Espie, Emmanuelle
Feikin, Daniel R.
Knoll, Maria Deloria
[J]. LANCET INFECTIOUS DISEASES, 2022, 22 (08): : 1114 - 1116

← 1 2 3 4 5 →