Mucosal vaccines: Strategies and challenges

被引：102
|
作者：
Li, Miao [1 ]
Wang, Yi [1 ]
Sun, Yuan [1 ]
Cui, Hongyu [1 ]
Zhu, Shu J. [2 ]
Qiu, Hua-Ji [1 ]
机构：
[1] Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China
[2] Zhejiang Univ, Coll Anim Sci, Hangzhou, Peoples R China
来源：
IMMUNOLOGY LETTERS | 2020年 / 217卷
基金：
中国博士后科学基金;
关键词：
Mucosal vaccine; Administration routes; Mucosal immune responses; Adjuvants; Targeted strategies; HEAT-LABILE ENTEROTOXIN; MOUSE PEYERS PATCH; DENDRITIC CELLS; IMMUNE-RESPONSES; ANTIBODY-RESPONSES; ESCHERICHIA-COLI; CHOLERA-TOXIN; T-CELLS; PROTECTIVE IMMUNITY; INFLUENZA VACCINES;
D O I：
10.1016/j.imlet.2019.10.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mucosal immunization has potential benefits over conventional parenteral immunization, eliciting immune defense in both mucosal and systemic tissue for protecting from pathogen invasion at mucosal surfaces. To provide a first line of protection at these entry ports, mucosal vaccines have been developed and hold a significant promise for reducing the burden of infectious diseases. However, until very recently, only limited mucosal vaccines are available. This review summarizes recent advances in selected aspects regarding mucosal vaccination, including appropriate administration routes, reasonable formulations, antigen-sampling and immune responses of mucosal immunity, and the strategies used to improve mucosal vaccine efficacy. Finally, the challenges of developing successful mucosal vaccines and the potential solutions are discussed.
引用
收藏
页码：116 / 125
页数：10
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