Animal models for evaluating antiepileptogenesis

The development of any new therapy for the treatment of a human disorder or disease depends heavily on the demonstration of efficacy in a validated animal model. The need for finding a therapy that would prevent or delay the development of epilepsy in the susceptible individual is evident, and many of the required tools have been developed in recent years. However, there are many practical challenges and hurdles that must be overcome before a "cure" can be realized. For an expanded treatment of this topic see Jasper's basic mechanisms of the epilepsies. 4th ed. (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at). © 2010 International League Against Epilepsy.