Emergency treatment of acute attacks in hereditary angioedema due to C1 inhibitor deficiency: what is the evidence?

被引：56
|
作者：
Longhurst, HJ [1 ]
机构：
[1] Barts & London NHS Trust, Dept Immunol, London EC1A 7BE, England
来源：
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2005年 / 59卷 / 05期
关键词：
hereditary angioedema; C1 esterase inhibitors; plasma;
D O I：
10.1111/j.1742-1241.2005.00352.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hereditary angioedema (HAE) is caused by a deficiency in C1 esterase-inhibitor (C1-INH) and is characterised by skin swelling, abdominal pain and episodes of upper respiratory tract obstruction. Oedema of the larynx can result in rapid asphyxiation and requires emergency treatment. Three treatment options for emergency treatment of HAE are reviewed: fresh frozen plasma, solvent/detergent-treated plasma and C1-INH concentrate. It is concluded that while all three treatment options are theoretically effective in the emergency treatment of HAE, C1-INH is the treatment of choice.
引用
收藏
页码：594 / 599
页数：6
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