High-resolution HLA-A, HLA-B, and HLA-DRB1 haplotype frequencies from the French Bone Marrow Donor Registry

被引:12
|
作者
Gourraud, Pierre-Antoine [1 ,2 ]
Pappas, Derek James [3 ]
Baouz, Amar [2 ]
Balere, Marie-Lorraine [2 ]
Garnier, Federico [2 ]
Marry, Evelyne [2 ]
机构
[1] Univ Calif San Francisco, Sch Med, Dept Neurol, San Francisco, CA 94158 USA
[2] Agence Biomed, Registre France Greffe Moelle, Paris, France
[3] Childrens Hosp Res Inst, Oakland, CA USA
关键词
Haplotype; Bone marrow donor registry; Hematopoietic stem cell donor; Peripheral blood stem cell donor cord blood bank; Genetic epidemiology; DIVERSITY; SELECTION; WORLDWIDE; BLOOD;
D O I
10.1016/j.humimm.2015.01.028
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We have estimated human leukocyte antigen (HLA) haplotype frequencies using the maximum likelihood mode, which accommodates typing ambiguities. The results of the frequency distribution of the 7015 haplotypes obtained are presented here. These include a total of 114 HLA-A, 185 HLA-B, and 76 HLA-DRB1 unique alleles at each locus. Across all populations, although the most common individual HLA alleles were HLA-A*02:01 (29.0%), HLA-B*07:02 (11.4%), and HLA-DRB1*07:01 (15.9%), the most frequent haplotype was found to be HLA-A*01:01 similar to B*08:01 similar to DRB1*03 :01. (C) 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:381 / 384
页数:4
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