Set similarity search, aiming to search the similar sets to a query set, has wide application in today's recommendation services. Meanwhile, the rapid advance in cloud technique has promoted the boom of data outsourcing. However, since the cloud is not fully trustable and the data may be sensitive, data should be encrypted before outsourced to the cloud. Undoubtedly, data encryption will hinder some basic functionalities, e.g., set similarity search. For achieving set similarity search over encrypted data, many solutions were proposed, yet they either only satisfy weak security requirements, or only achieve approximate similarity, or have low efficiency or under the model of two cloud servers. Therefore, in this article, we propose a new efficient and privacy-preserving exact set similarity search scheme under a single cloud server. Specifically, we first design a symmetric-key predicate encryption (SPE-Sim) scheme, which can support similarity search over binary vectors. Then, we represent the set records to be binary vectors and employ the B+ tree to build an index for them. After that, based on SPE-Sim and the B+ tree-based index, we propose our scheme and it can achieve efficient set similarity search while preserving the privacy of set records and query contents. Finally, security analysis and performance evaluation indicate that our scheme is privacy-preserving and efficient.