Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria

被引：410
|
作者：
Wells, Jerry M. [1 ]
Mercenier, Annick [2 ]
机构：
[1] Univ Wageningen & Res Ctr, Dept Anim Sci, NL-6700 AH Wageningen, Netherlands
[2] Nestle Res Ctr, CH-1000 Lausanne, Switzerland
来源：
NATURE REVIEWS MICROBIOLOGY | 2008年 / 6卷 / 05期
关键词：
D O I：
10.1038/nrmicro1840
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Studies of lactic acid bacteria (LAB) as delivery vehicles have focused mainly on the development of mucosal vaccines, with much effort being devoted to the generation of genetic tools for antigen expression in different bacterial locations. Subsequently, interleukins have been co-expressed with antigens in LAB to enhance the immune response that is raised against the antigen. LAB have also been used as a delivery system for a range of molecules that have different applications, including anti-infectives, therapies for allergic diseases and therapies for gastrointestinal diseases. Now that the first human trial with a Lactococcus strain that expresses recombinant interleukin-10 has been completed, we discuss what we have learnt, what we do not yet understand and what the future holds for therapy and prophylaxis with LAB.
引用
收藏
页码：349 / 362
页数：14
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