Genetic Variation of Myeloperoxidase Gene Contributes to Preeclampsia: A Preliminary Association Study in Turkish Population

Objective. To examine MPO gene polymorphisms of women with preeclampsia in Turkish population. Methods. Sixty-one preeclamptic and 61 normotensive women without history of preeclampsia in earlier pregnancies were enrolled in this prospective controlled study. MPO mutations were characterized by PCR-RFLP method. Results. We demonstrated a significant difference in patients with preeclampsia in terms of genotype frequency. Heterozygous carriers of -463A among preeclamptic pregnancies were significantly frequent, whereas rare A/A homozygotes failed to differ from controls. Conclusion. The -463G/A polymorphism of leukocyte MPO could be an intriguing susceptibility factor that modulates an individual's risk of preeclampsia in Turkish population.