Synthesis and evaluation of wound healing properties of hydro-diab hydrogel loaded with green-synthetized AGNPS: in vitro and in ex vivo studies

被引：15
|
作者：
Ruffo, Mariarosa [1 ,2 ]
Parisi, Ortensia Ilaria [1 ,2 ]
Dattilo, Marco [1 ]
Patitucci, Francesco [1 ,2 ]
Malivindi, Rocco [1 ,2 ]
Pezzi, Vincenzo [1 ,2 ]
Tzanov, Tzanko [3 ]
Puoci, Francesco [1 ,2 ]
机构：
[1] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, CS, Italy
[2] Univ Calabria, Dept Pharm Hlth & Nutr Sci, Macrofarm SRL, I-87036 Arcavacata Di Rende, Italy
[3] Univ Politecn Cataluna, Dept Chem Engn, Mol & Ind Biotechnol Grp, Terrassa, Spain
来源：
DRUG DELIVERY AND TRANSLATIONAL RESEARCH | 2022年 / 12卷 / 08期
关键词：
Diabetic foot ulcerations (DFUs); Silver nanoparticles; Green-synthesis; Hydrogel; Wound healing; SILVER NANOPARTICLES; INFECTION-CONTROL; ANTIBACTERIAL; BIOMATERIALS; FIBROBLASTS; RESPONSES; CELLS; PH;
D O I：
10.1007/s13346-022-01121-w
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
In diabetic patients, the presence of neuropathy, peripheral vascular diseases and ischemia, leads to the formation of foot ulcerations with a higher risk of infection because the normal response to bacterial infection is missing. In the aim to control and treat diabetic foot ulcerations (DFUs), wound dressings that are able to absorb exudate, to prevent infections, and to promote wound healing are needed. For this reason, the aim of the present research was to synthetize a biocompatible hydrogel (called HyDrO-DiAb) composed of carboxymethylcellulose loaded with silver nanoparticles (AgNPs) for the treatment of diabetic foot ulcers. In this study, AgNPs were obtained by a green synthesis and, then, were dissolved in a CMC hydrogel that, after a freeze drying process, becomes a flexible and porous structure. The in vitro and in ex vivo wound healing activity of the obtained HyDrO-DiAb hydrogel was evaluated.
引用
收藏
页码：1881 / 1894
页数：14
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