Powder disperser for the continuous aerosolizing of dry powdered nanoparticles

被引:3
|
作者
Tu, Chengxu [1 ]
Lin, Jianzhong [2 ]
Yin, Zhaoqin [1 ]
Bao, Fubing [1 ]
Du, Pengfei [1 ]
机构
[1] China Jiliang Univ, Zhejiang Prov Key Lab Flow Measurement Technol, Hangzhou 310018, Zhejiang, Peoples R China
[2] Zhejiang Univ, State Key Lab Fluid Power Transmiss & Control, Hangzhou 310027, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
Nanoparticles; Powder disperser; Continuous aerosolizing; Particle size distribution; Dosing rate; PARTICLES; GENERATION; CATALYSIS; IMPACT; RANGE;
D O I
10.1016/j.apt.2017.08.011
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
A new method has been developed for the continuous aerosolization of dry powdered nanoparticles using a commercially available and cost-effective vacuum generator. A commercial doser was used to supply nanoparticles continuously and precisely. A novel device (called a pressure equilibrium unit) was designed to connect the doser and the vacuum generator to make sure both parts avoid suffering from pressure shock. This system is denoted as a continuous vacuum generator disperser (CVGD). The dosing rate of the CVGD for different particle materials tends to a constant value. All the aerosolized engineered nanoparticles (ENPs) of varying materials and primary diameter obtained through the CVGD distribute identically log-normally as a whole. It is more difficult to separate the nanoparticles of smaller primary diameter using the CVGD, due to the stronger van der Waals attractive force between them. The total particle concentration can be adjusted easily by changing the motor speed of the doser (Dr), which was directly proportional to the dosing rate. As Dr increased, the PSDs shifted to a larger diameter to some extent. For sufficient large dosing rates, the CVGD performance could be improved significantly by increasing the inlet pressure of the vacuum generator (P-j). (C) 2017 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.
引用
收藏
页码:2848 / 2858
页数:11
相关论文
共 50 条
  • [1] A Cost-Effective Method of Aerosolizing Dry Powdered Nanoparticles
    Tiwari, Andrea J.
    Fields, Caleb G.
    Marr, Linsey C.
    [J]. AEROSOL SCIENCE AND TECHNOLOGY, 2013, 47 (11) : 1267 - 1275
  • [2] INTRODUCTION OF POWDERED SOLID SAMPLES AS AEROSOLS INTO THE INDUCTIVELY COUPLED PLASMA USING A POWDER DISPERSER
    PFANNERSTILL, PE
    CREED, JT
    DAVIDSON, TM
    CARUSO, JA
    WILLEKE, K
    [J]. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, 1990, 5 (04) : 285 - 291
  • [3] MODIFIED HARVARD DRY DUST DISPERSER
    CILIBERTI, DF
    LANCASTER, BW
    [J]. REVIEW OF SCIENTIFIC INSTRUMENTS, 1975, 46 (07): : 929 - 930
  • [4] Performance of Low Air Volume Dry Powder Inhalers (LV-DPI) when Aerosolizing Excipient Enhanced Growth (EEG) Surfactant Powder Formulations
    Boc, Susan
    Momin, Mohammad A. M.
    Farkas, Dale R.
    Longest, Worth
    Hindle, Michael
    [J]. AAPS PHARMSCITECH, 2021, 22 (04)
  • [5] Performance of Low Air Volume Dry Powder Inhalers (LV-DPI) when Aerosolizing Excipient Enhanced Growth (EEG) Surfactant Powder Formulations
    Susan Boc
    Mohammad A. M. Momin
    Dale R. Farkas
    Worth Longest
    Michael Hindle
    [J]. AAPS PharmSciTech, 22
  • [7] IMPROVEMENT OF THE MIXER-TYPE POWDER DISPERSER
    GOTOH, K
    YOSHIDA, T
    MASUDA, H
    [J]. ADVANCED POWDER TECHNOLOGY, 1994, 5 (04) : 323 - 337
  • [8] Spray freeze drying for dry powder inhalation of nanoparticles
    Ali, Mohamed Ehab
    Lamprecht, Alf
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2014, 87 (03) : 510 - 517
  • [9] Pulmonary delivery of inhalable nanoparticles: dry powder inhalers
    Al-Hallak, M. H. D. Kamal
    Sarfraz, Muhammad Khan
    Azarmi, Shirzad
    Roa, Wilson H.
    Finlay, Warren H.
    Lobenberg, Raimar
    [J]. THERAPEUTIC DELIVERY, 2011, 2 (10) : 1313 - 1324
  • [10] Evaluation of the TSI small-scale powder disperser
    Chen, BT
    Yeh, HC
    Fan, BJ
    [J]. JOURNAL OF AEROSOL SCIENCE, 1995, 26 (08) : 1303 - 1313