Direct HPLC separation of indenolol enantiomers using a cellulose chiral stationary phase

被引：12
|
作者：
AboulEnein, HY
Serignese, V
机构：
[1] Bioanalyt. and Drug Devmt. Lab., Biological and Medical Research, King Faisal Specialist Hosp. Res. C., Riyadh 11211
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 1996年 / 19卷 / 06期
关键词：
D O I：
10.1080/10826079608001923
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Racemic indenolol was resolved into its individual enantiomers by high performance liquid chromatography (HPLC) using a commercially available cellulose tris (3,5-dimethylphenyl carbamate) chiral stationary phase, known as Chiralcel OD. Indenolol contains two positional isomers, giving it a total of four enantiomers. The enantiomeric ratio was validated and peak identification for each enantiomer was established according to their optical rotation sign.
引用
收藏
页码：933 / 938
页数：6
相关论文
共 50 条
  • [1] DIRECT HPLC SEPARATION OF GLUTETHIMIDE ENANTIOMERS USING A CELLULOSE TRICINNAMATE CHIRAL STATIONARY PHASE
    ABOULENEIN, HY
    ISLAM, MR
    [J]. ACTA PHARMACEUTICA NORDICA, 1990, 2 (06): : 415 - 420
  • [2] DIRECT HPLC SEPARATION OF THALIDOMIDE ENANTIOMERS USING CELLULOSE TRIS-4-METHYLPHENYL BENZOATE CHIRAL STATIONARY PHASE
    ABOULENEIN, HY
    ISLAM, MR
    [J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1991, 14 (04): : 667 - 673
  • [3] Chiral separation of six tetralone derivative enantiomers using immobilized cellulose chiral stationary phase
    Zhao Yunfeng
    Song Jiaxin
    Sun Jiayi
    Yuan Xiaowei
    Guo Xingjie
    [J]. CHINESE JOURNAL OF CHROMATOGRAPHY, 2014, 32 (08) : 832 - 836
  • [4] HPLC SEPARATION OF PENTAZOCINE ENANTIOMERS IN SERUM USING AN OVOMUCOID CHIRAL STATIONARY-PHASE
    KELLY, JW
    STEWART, JT
    BLANTON, CD
    [J]. BIOMEDICAL CHROMATOGRAPHY, 1994, 8 (05) : 255 - 257
  • [5] Separation of nicotine and nornicotine enantiomers via normal phase HPLC on derivatized cellulose chiral stationary phases
    Tang, YB
    Zielinski, WL
    Bigott, HM
    [J]. CHIRALITY, 1998, 10 (04) : 364 - 369
  • [6] SEPARATION OF BETAXOLOL HYDROCHLORIDE WITH NEW BONDED CELLULOSE CHIRAL STATIONARY PHASE AND DETERMINATION OF THE ENANTIOMERS IN PLASMA BY HPLC
    Zhou, Jie
    Liu, Qian
    Su, Nan
    Fu, Guangjun
    Pei, Wenjuan
    Zhang, Zhenzhong
    [J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2012, 35 (13) : 1767 - 1778
  • [7] SEPARATION OF SULFOXIDE ENANTIOMERS BY HPLC UPON A CHIRAL FLUOROALCOHOLIC STATIONARY PHASE
    PIRKLE, WH
    HOUSE, DW
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1978, 175 (MAR): : 151 - 151
  • [8] Chromatographic separation of fluoxetine hydrochloride enantiomers by cellulose chiral stationary phase
    Zhou, J
    Ren, QL
    Wu, PD
    [J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2005, 28 (20) : 3229 - 3242
  • [9] Direct HPLC separation of enantiomers of pantoprazole and other benzimidazole sulfoxides using cellulose-based chiral stationary phases in reversed-phase mode
    Tanaka, M
    Yamazaki, H
    Hakusui, H
    [J]. CHIRALITY, 1995, 7 (08) : 612 - 615
  • [10] Fundamental study of enantioselective HPLC separation of tapentadol enantiomers using cellulose-based chiral stationary phase in normal phase mode
    Dousa, Michal
    Lehnert, Petr
    Adamusova, Hana
    Bosakova, Zuzana
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2013, 74 : 111 - 116
12345