Direct HPLC separation of indenolol enantiomers using a cellulose chiral stationary phase

被引:12
|
作者
AboulEnein, HY
Serignese, V
机构
[1] Bioanalyt. and Drug Devmt. Lab., Biological and Medical Research, King Faisal Specialist Hosp. Res. C., Riyadh 11211
关键词
D O I
10.1080/10826079608001923
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Racemic indenolol was resolved into its individual enantiomers by high performance liquid chromatography (HPLC) using a commercially available cellulose tris (3,5-dimethylphenyl carbamate) chiral stationary phase, known as Chiralcel OD. Indenolol contains two positional isomers, giving it a total of four enantiomers. The enantiomeric ratio was validated and peak identification for each enantiomer was established according to their optical rotation sign.
引用
收藏
页码:933 / 938
页数:6
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