Sex- and Estrus-Dependent Differences in Rat Basolateral Amygdala

被引:120
|
作者
Blume, Shannon R. [1 ]
Freedberg, Mari [1 ]
Vantrease, Jaime E. [1 ]
Chan, Ronny [1 ]
Padival, Mallika [1 ]
Record, Matthew J. [1 ]
DeJoseph, M. Regina [2 ]
Urban, Janice H. [2 ]
Rosenkranz, J. Amiel [1 ]
机构
[1] Rosalind Franklin Univ, Chicago Med Sch, Dept Cellular & Mol Pharmacol, 3333 Green Bay Rd, N Chicago, IL 60064 USA
[2] Rosalind Franklin Univ, Chicago Med Sch, Dept Physiol & Biophys, N Chicago, IL 60064 USA
来源
JOURNAL OF NEUROSCIENCE | 2017年 / 37卷 / 44期
基金
美国国家卫生研究院;
关键词
amygdala; electrophysiology; estrous; fear extinction; female; DENDRITIC SPINE DENSITY; CALCIUM-BINDING PROTEINS; MEDIAL PREFRONTAL CORTEX; SOCIAL ANXIETY DISORDER; TERM POTENTIATION LTP; FEAR EXTINCTION; GENDER-DIFFERENCES; ESTROUS-CYCLE; NEURONAL-ACTIVITY; PYRAMIDAL CELLS;
D O I
10.1523/JNEUROSCI.0758-17.2017
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Depression and anxiety are diagnosed almost twice as often in women, and the symptomology differs in men and women and is sensitive to sex hormones. The basolateral amygdala (BLA) contributes to emotion-related behaviors that differ between males and females and across the reproductive cycle. This hints at sex-or estrus-dependent features of BLA function, about which very little is known. The purpose of this study was to test whether there are sex differences or estrouscyclicity in rat BLA physiology and to determine their mechanistic correlates. We found substantial sex differences in the activity of neurons in lateral nuclei (LAT) and basal nuclei (BA) of the BLA that were associated with greater excitatory synaptic input in females. We also found strong differences in the activity of LAT and BA neurons across the estrous cycle. These differences were associated with a shift in the inhibition-excitation balance such that LAT had relatively greater inhibition during proestrus which paralleled more rapid cued fear extinction. In contrast, BA had relatively greater inhibition during diestrus that paralleled more rapid contextual fear extinction. These results are the first to demonstrate sex differences in BLA neuronal activity and the impact of estrous cyclicity on these measures. The shift between LAT and BA predominance across the estrous cycle provides a simple construct for understanding the effects of the estrous cycle on BLA-dependent behaviors. These results provide a novel framework to understand the cyclicity of emotional memory and highlight the importance of considering ovarian cycle when studying the BLA of females.
引用
收藏
页码:10567 / 10586
页数:20
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