Synthesis and assignment of stereochemistry of the antibacterial cyclic peptide xenematide

被引：19

作者：

Hung, Kuo-yuan ^{[1
]}

Harris, Paul W. R. ^{[1
]}

Heapy, Amanda M. ^{[1
]}

Brimble, Margaret A. ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, Auckland, New Zealand

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 01期

关键词：

RESISTANCE;

D O I：

10.1039/c0ob00315h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the antimicrobial cyclic peptide xenematide was accomplished by Fmoc solid phase peptide synthesis and the key esterification reaction was achieved using a modified Yamaguchi esterification. Comparison of the optical rotation and NMR data of the synthesized diastereomers to that of the natural product confirmed the structure of xenematide to be PA-L-[Thr-L-Trp-D-Trp-beta-Ala]. (PA = phenylacetyl).

引用

页码：236 / 242

页数：7

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