Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient

被引：4
|
作者：
Chen, Yuchang [1 ]
Ou, Zhanhui [1 ]
Song, Bing [1 ]
Xian, Yexing [1 ]
Ouyang, Shuming [1 ]
Xie, Yuhuan [1 ]
Xue, Yanting [1 ]
Sun, Xiaofang [1 ]
机构：
[1] Guangzhou Med Univ, Affiliated Hosp 3, Key Lab Major Obstetr Dis Guangdong Prov, Key Lab Reprod & Genet,Guangdong Higher Educ Inst, Guangzhou 510150, Guangdong, Peoples R China
来源：
STEM CELL RESEARCH | 2017年 / 23卷
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.scr.2017.06.002
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
47, XXX syndrome is one of several sex-chromosomal aneuploidies, and it has an incidence of approximately 1/ 1000 in newborn females. Because of heterogeneity in X-inactivation, these patients may exhibit a variety of clinical symptoms. Here, we report the generation of an integration-free human induced pluripotent stem cell line (GZHMUi001-A) by using Sendai virus to reprogram peripheral blood mononuclear cells from a 47, XXX syndrome patient with premature ovarian failure. This 47, XXX iPS cell line has characteristics of pluripotent stem cells and is a useful tool for the investigation of this X chromosome aneuploid disease. (C) 2017 Published by Elsevier B.V.
引用
收藏
页码：57 / 60
页数：4
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