STEROID-RESISTANT ASTHMA

被引：18
|
作者：
Yim, Robert P. [1 ]
Koumbourlis, Anastassios C. [1 ]
机构：
[1] George Washington Univ, Childrens Natl Med Ctr, Sch Med, Div Pulm & Sleep Med, Washington, DC 20010 USA
来源：
PAEDIATRIC RESPIRATORY REVIEWS | 2012年 / 13卷 / 03期
关键词：
Asthma; Steroid-resistance; Phenotypes; Mechanisms; Treatment; Children; GLUCOCORTICOID RESISTANCE; CORTICOSTEROID RESISTANCE; AIRWAY INFLAMMATION; MECHANISMS; OMALIZUMAB; PHENOTYPES; SPUTUM; IDENTIFICATION; EXACERBATIONS; MEPOLIZUMAB;
D O I：
10.1016/j.prrv.2011.05.002
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Steroid-resistant asthma (SRA) refers to patients with symptoms consistent with asthma who show very poor or no response at all to high doses of inhaled or even of systemic corticosteroids. The current article reviews the SRA related literature focusing on the problems associated with the definition of SRA (especially its association with difficult to control, or severe asthma), its various phenotypes, its molecular basis, and the potential treatment options. The article also discusses the limitations of some of the key criteria used for the determination of SRA and proposes a modified set of criteria that are more applicable to children. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：172 / 177
页数：6
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