Ti-Catalyzed Multicomponent Oxidative Carboamination of Alkynes with Alkenes and Diazenes

被引：55
|
作者：
Davis-Gilbert, Zachary W. [1 ]
Yao, Letitia J. [1 ]
Tonks, Ian A. [1 ]
机构：
[1] Univ Minnesota Twin Cities, Dept Chem, 207 Pleasant St SE, Minneapolis, MN 55455 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 44期
基金：
美国国家卫生研究院;
关键词：
REDUCTIVE ELIMINATION; COMPLEXES; IMINES; BONDS; CYCLOADDITION; ADDITIONS; CARBON; TI(IV);
D O I：
10.1021/jacs.6b09939
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The inter- or intramolecular oxidative carboamination of alkynes catalyzed by [py(2)TiCl(2)NPh](2) is reported. These multicomponent reactions couple alkenes, alkynes and diazenes to form either alpha,beta-unsaturated imines or alpha-(iminomethyl)cyclopropanes via a Ti-II/Ti-IV redox cycle. Each of these products is formed from a common azatitanacyclohexene intermediate that undergoes either beta-H elimination or alpha,gamma-coupling, wherein the selectivity is under substrate control.
引用
收藏
页码：14570 / 14573
页数：4
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