Intramolecular 1,3-dipolar nitrone cycloaddition route to bicyclic fused enediyne

被引：10
|
作者：
Basak, A [1 ]
Ghosh, SC [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 43期
关键词：
enediynes; nitrone cycloaddition; regioselective; Bergman cyclization; Sonogashira coupling;
D O I：
10.1016/j.tetlet.2005.08.125
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Bicyclic isooxazolidinyl enediynes I and 2 have been prepared by intramolecular nitrone cycloaddition between the two arms of an acyclic enediyne precursor 13. The reaction is highly regioselective and the two configurational isomers have similar onset temperatures for BC indicating no influence of bridgehead stereochemistry on the kinetics of cyclization. (c) 2005 Published by Elsevier Ltd.
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收藏
页码：7385 / 7388
页数：4
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