Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015

被引：93

作者：

Hurt, Aeron C. ^{[1
,2
]}

Besselaar, Terry G. ^{[3
]}

Daniels, Rod S. ^{[4
]}

Ermetal, Burcu ^{[4
]}

Fry, Alicia ^{[5
]}

Gubareva, Larisa ^{[5
]}

Huang, Weijuan ^{[6
]}

Lackenby, Angie ^{[7
]}

Lee, Raphael T. C. ^{[8
]}

Lo, Janice ^{[9
]}

Maurer-Stroh, Sebastian ^{[8
,10
,11
]}

Nguyen, Ha T. ^{[5
]}

Pereyaslov, Dmitriy ^{[12
]}

Rebelo-de-Andrade, Helena ^{[13
,14
]}

Siqueira, Marilda M. ^{[15
]}

Takashita, Emi ^{[16
]}

Tashiro, Masato ^{[16
]}

Tilmanis, Danielle ^{[1
]}

Wang, Dayan ^{[6
]}

Zhang, Wenqing ^{[3
]}

Meijer, Adam ^{[17
]}

机构：

[1] Peter Doherty Inst Infect & Immun, VIDRL, WHO Collaborating Ctr Reference & Res Influenza, 792 Elizabeth St, Melbourne, Vic 3000, Australia

[2] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Parkville, Vic 3010, Australia

[3] WHO, Global Influenza Programme, Ave Appia 20, CH-1211 Geneva 27, Switzerland

[4] Natl Inst Med Res, MRC, Francis Crick Inst, WIC,Mill Hill Lab,WHO CC Reference & Res Influenz, Ridgeway, London NW7 1AA, England

[5] Ctr Dis Control & Prevent, WHO Collaborating Ctr Surveillance Epidemiol & Co, 1600 Clifton RD NE,MS-G16, Atlanta, GA USA

[6] China CDC, Natl Inst Viral Dis Control & Prevent, WHO Collaborating Ctr Reference & Res Influenza, Collaborat Innovat Ctr Diag & Treatment Infect Di, Beijing, Peoples R China

[7] Publ Hlth England, Natl Infect Serv, London NW9 5HT, England

[8] Agcy Sci Technol & Res, Bioinformat Inst, 30 Biopolis St,07-01, Singapore 138671, Singapore

[9] Publ Hlth Lab Ctr, 382 Nam Cheong St, Hong Kong, Hong Kong, Peoples R China

[10] Nanyang Technol Univ, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore

[11] Minist Hlth, Natl Publ Hlth Lab, 3 Biopolis Dr,Synapse 05-14 16, Singapore 138623, Singapore

[12] WHO, Reg Off Europe, Div Communicable Dis Hlth Secur & Environm, Marmorvej 51, DK-2100 Copenhagen, Denmark

[13] Inst Nacl Saude, Av Padre Cruz, P-1649016 Lisbon, Portugal

[14] Univ Lisbon, Fac Farm, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal

[15] Fiocruz MS, Inst Oswaldo Cruz, Natl Influenza Ctr, Lab Virus Resp, Rio De Janeiro, Brazil

[16] Natl Inst Infect Dis, WHO Collaborating Ctr Reference & Res Influenza, Gakuen 4-7-1, Tokyo 2080011, Japan

[17] Natl Inst Publ Hlth & Environm, POB 1, NL-3720 BA Bilthoven, Netherlands

来源：

ANTIVIRAL RESEARCH | 2016年 / 132卷

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

Influenza virus; Antiviral resistance; Neuraminidase inhibitors; Oseltamivir; Global analysis; Reduced susceptibility; OSELTAMIVIR; RESISTANT;

D O I：

10.1016/j.antiviral.2016.06.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The World Health Organization (WHO) Collaborating Centres for Reference and Research on Influenza (WHO CCs) tested 13,312 viruses collected by WHO recognized National Influenza Centres between May 2014 and May 2015 to determine 50% inhibitory concentration (IC50) data for neuraminidase inhibitors (NAIs) oseltamivir, zanamivir, peramivir and laninamivir. Ninety-four per cent of the viruses tested by the WHO CCs were from three WHO regions: Western Pacific, the Americas and Europe. Approximately 0.5% (n = 68) of viruses showed either highly reduced inhibition (HRI) or reduced inhibition (RI) (n = 56) against at least one of the four NAIs. Of the twelve viruses with HRI, six were A(H1N1)pdm09 viruses, three were A(H3N2) viruses and three were B/Yamagata-lineage viruses. The overall frequency of viruses with RI or HRI by the NAIs was lower than that observed in 2013-14 (1.9%), but similar to the 2012-13 period (0.6%). Based on the current analysis, the NAIs remain an appropriate choice for the treatment and prophylaxis of influenza virus infections. (C) 2016 The Authors. Published by Elsevier B.V.

引用

页码：178 / 185

页数：8

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