Significance of gut microbiota in alcoholic and non-alcoholic fatty liver diseases

被引：15

作者：

Sharma, Satya Priya ^{[1
]}

Suk, Ki Tae ^{[1
]}

Kim, Dong Joon ^{[1
]}

机构：

[1] Hallym Univ, Coll Med, Inst Liver & Digest Dis, Chunchon 24252, South Korea

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2021年 / 27卷 / 37期

基金：

新加坡国家研究基金会;

关键词：

Fatty liver disease; Alcoholic fatty liver disease; Non-alcoholic fatty liver disease; Gut microbiome; Dysbiosis; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; BILE-ACIDS; DYSBIOSIS; HOST; BACTERIAL; SUPPLEMENTATION; CIRRHOSIS; FIBROSIS; ETHANOL;

D O I：

10.3748/wjg.v27.i37.6161

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Liver-gut communication is vital in fatty liver diseases, and gut microbes are the key regulators in maintaining liver homeostasis. Chronic alcohol abuse and persistent overnutrition create dysbiosis in gut ecology, which can contribute to fatty liver disease. In this review, we discuss the gut microbial compositional changes that occur in alcoholic and nonalcoholic fatty liver diseases and how this gut microbial dysbiosis and its metabolic products are involved in fatty liver disease pathophysiology. We also summarize the new approaches related to gut microbes that might help in the diagnosis and treatment of fatty liver disease.

引用

页码：6161 / 6179

页数：19

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