Protic ionic liquids as constituent of aqueous two-phase system based on acetonitrile: Synthesis, phase diagrams and genipin pre-purification

被引：15
|
作者：
Alves Camelo, Lidia Cristina [1 ]
Dias Santos, Gabriela de Souza [1 ]
de Souza, Ranyere Lucena [1 ,2 ]
Faria Soares, Cleide Mara [1 ,2 ]
Brandao Pereira, Jorge Fernando [3 ]
Lima, Alvaro Silva [1 ,2 ]
机构：
[1] Univ Tiradentes, Programa Posgrad Engn Proc, Av Murilo Dantas 300, BR-49032490 Aracaju, Sergipe, Brazil
[2] Inst Tecnol & Pesquisa, Av Murilo Dantas 300, BR-49032490 Aracaju, Sergipe, Brazil
[3] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Bioproc & Biotechnol, Rodovia Araraquara Jau Km 01, BR-14800903 Araraquara, SP, Brazil
来源：
FLUID PHASE EQUILIBRIA | 2020年 / 507卷
基金：
巴西圣保罗研究基金会;
关键词：
Protic ionic liquid; Phase equilibria; Genipin; Extraction; Integrated process; THERMOPHYSICAL PROPERTIES; BIOACTIVE COMPOUNDS; WATER MIXTURES; EXTRACTION; RECOVERY; GENIPOSIDE; SEPARATION; SOLVENTS; QUANTIFICATION; L;
D O I：
10.1016/j.fluid.2019.112425
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
The aim of this study was to evaluate the formation of aqueous two-phase systems (ATPS) based on different protic ionic liquids (PIL), synthesized using amines, and organic or inorganic acid, and acetonitrile (ACN). The ATPSs are used to pre-purify genipin from genipap (Genipa americana L.). All PILs (purity above 98%) were able to form ATPSs with ACN, the size of the biphasic region being directly dependent on salting-out aptitude of PIL anions and relative hydrophilicity of the corresponding cations. The highest solid liquid extraction of genipin from genipap was achieved by using aqueous ACN solution at 75% (16.79 +/- 0.06 mg g(-1) dry raw material) as extractant. After the extraction stage, the ATPS was used as an integrated platform to pre-purify the genipin present in the extract. Three different overall mixture point compositions were tested, and those formed by [MEA][H(2)Cit] (25 wt%) + ACN (45 wt%) + water (30 wt%) at 298.15 +/- 1.00 K and 0.10 +/- 0.01 MPa showed the highest selectivity (S = 4.202 +/- 0.009) and recovery of genipin in top phase (R-TG = 56.74 +/- 0.04%), and the purification factor in top phase was 5.9 fold. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页数：11
相关论文
共 50 条
  • [1] Pre-purification of genipin from genipap using aqueous-two-phase systems composed of protic ionic liquids plus polymers + water at 298 K and atmospheric pressure
    Camelo, Lidia Cristina Alves
    Santos, Gabriela de Souza Dias
    de Souza, Ranyere Lucena
    Soares, Cleide Mara Faria
    Pereira, Jorge Fernando Brandao
    Lima, Alvaro Silva
    [J]. SEPARATION AND PURIFICATION TECHNOLOGY, 2021, 256
  • [2] Protic ionic liquids as a constituent of biphasic systems based on acetonitrile: Phase diagram and alkaloid partitioning
    Placido, Nilmara S. O.
    Carlos, Andre L. S.
    Galvao, Joseph U. S.
    Souza, Ranyere L.
    Soares, Cleide M. F.
    Mattedi, Silvana
    Fricks, Alini T.
    Lima, Alvaro S.
    [J]. SEPARATION AND PURIFICATION TECHNOLOGY, 2018, 200 : 318 - 326
  • [3] Poly(vinyl alcohol) as a novel constituent to form aqueous two-phase systems with acetonitrile: Phase diagrams and partitioning experiments
    Cardoso, Gustavo de Brito
    Souza, Isabela Nascimento
    Pereira, Matheus M.
    Costa, Luiz Pereira
    Freire, Mara G.
    Faria Soares, Cleide Mara
    Lima, Alvaro Silva
    [J]. CHEMICAL ENGINEERING RESEARCH & DESIGN, 2015, 94 : 317 - 323
  • [4] Phase behavior of ionic liquids (II) Aqueous two-phase
    Xia, Hansong
    Yu, Jiang
    Hu, Xuesheng
    Liu, Qingfen
    Liu, Huizhou
    [J]. Huagong Xuebao/Journal of Chemical Industry and Engineering (China), 2006, 57 (09): : 2149 - 2151
  • [5] Choline derivative ionic liquids-based aqueous two-phase systems: Phase diagrams and partition of purine alkaloids
    Ren, Jiao
    Li, Zhiyong
    Liu, Jing
    Pei, Yuanchao
    Wang, Huiyong
    Wang, Jianji
    [J]. JOURNAL OF CHEMICAL THERMODYNAMICS, 2018, 118 : 51 - 57
  • [6] Lipase purification using ionic liquids as adjuvants in aqueous two-phase systems
    Souza, Ranyere L.
    Ventura, Sonia P. M.
    Soares, Cleide M. F.
    Coutinho, Joao A. P.
    Lima, Alvaro S.
    [J]. GREEN CHEMISTRY, 2015, 17 (05) : 3026 - 3034
  • [7] Extraction of Proteins with Aqueous Two-Phase Systems Formed by Protic Ionic Liquids and Inorganic Salts
    Matsumoto, Michiaki
    Shinji, Fumiya
    Tahara, Yoshiro
    [J]. SOLVENT EXTRACTION RESEARCH AND DEVELOPMENT-JAPAN, 2021, 28 (02) : 141 - 148
  • [8] Selective extraction of female hormones using aqueous two-phase system composed of double protic ionic liquid plus acetonitrile
    Buarque, Filipe S.
    Barreto, Victor S.
    Soares, Cleide M. F.
    Souza, Ranyere L.
    Pereira, Matheus M.
    Lima, Alvaro S.
    [J]. FLUID PHASE EQUILIBRIA, 2020, 508 (508)
  • [9] Aqueous two-phase systems formed by maltodextrin and acetonitrile: Phase diagrams and partitioning studies
    Souza, Isabela N.
    Soares, Cleide M. F.
    Souza, Ranyere L.
    Freire, Mara G.
    Lima, Alvaro Silva
    [J]. FLUID PHASE EQUILIBRIA, 2018, 476 : 179 - 185
  • [10] Ionic liquids aqueous two-phase system and its research in proteins' extraction
    [J]. Liu, X, 1600, Editor. Dept. of J. of the Chinese Cereals and Oils Assoc., No. 11 Baiwanzhuang Avenue, Xicheng District, Beijing, 100037, China (28):
12345