Synthesis of functionalized benzimidazoles via oxidative tandem quartic C-H aminations and cleavage of C-N and C-C bonds

被引：4

作者：

Liang, Taoyuan ^{[1
]}

Zhao, He ^{[1
]}

Gong, Lingzhen ^{[1
]}

Jiang, Huanfeng ^{[1
]}

Zhang, Min ^{[1
,2
]}

机构：

[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Wushan Rd 381, Guangzhou 510641, Peoples R China

[2] Qingyuan Huayuan Inst Sci & Technol Collaborat In, Qingyuan 511500, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 96期

基金：

中国国家自然科学基金;

关键词：

COPPER-CATALYZED SYNTHESIS;

D O I：

10.1039/d1cc05521f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Via aerobic copper-catalyzed tandem quartic C-H aminations, we herein present an unprecedented approach for the synthesis of functionalized benzimidazoles from aniline derivatives and 2-substituted cyclic amines. The cyclic amines act as the C=N building blocks and are involved in the annulation reaction by cleavage of inert alpha-C-N and beta-C-C bonds. The synthetic protocol features high selectivity, no need for specific aminating agents, mild conditions, and the use of a naturally abundant [Cu]/O-2 catalyst system.

引用

页码：12976 / 12979

页数：4

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