Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma-cyclodextrin as chiral solvating agent

Following an extended chiral drug screening program by capillary zone electrophoresis (CZE), the enantioseparation of 86 racemic drugs was tested with gamma-cyclodextrin as a chiral solvating agent. Unified conditions were applied to all experiments. In total, 18 drug racemates were separated, 13 entries thereof that had not been separated at the lower CSA concentration applied in an earlier stage of the project. A comparison of the data with the results obtained for alpha- and beta-cyclodextrin points to the significance of partial penetration ("side-on binding") of aryl groups into the cyclodextrin cavity. Chirality 10:548-554, 1998. (C) 1998 Wiley-Liss, Inc.