Role of 4-hydroxy-trans-2-nonenal in cell functions

被引：43
|
作者：
Dubinina, E. E. [1 ]
Dadali, V. A. [2 ]
机构：
[1] Bekhterev St Petersburg Psychoneurol Res Inst, St Petersburg 192019, Russia
[2] Mechnikov St Petersburg State Med Acad, St Petersburg 195067, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2010年 / 75卷 / 09期
关键词：
4-hydroxy-trans-2-nonenal; lipid peroxidation; apoptosis; glutathione system; carotenoids; oxidative stress; LIPID-PEROXIDATION PRODUCT; GLUTATHIONE-S-TRANSFERASE; LOW-DENSITY-LIPOPROTEIN; ACTIVATED PROTEIN-KINASE; ACID-BINDING PROTEIN; ACETYL-L-CARNITINE; GAMMA-GLUTAMYL-TRANSPEPTIDASE; POLYUNSATURATED FATTY-ACIDS; TRANSIENT FOCAL ISCHEMIA; AMYLOID-BETA-PEPTIDE;
D O I：
10.1134/S0006297910090014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The role of lipid peroxidation product 4-hydroxy-trans-2-nonenal (4-HNE) in functional activity of cells under normal and different pathological conditions is discussed. Different pathways of 4-HNE metabolism in tissues are analyzed, with particular focus on the role the glutathione system in this process. 4-HNE is implicated in regulation of cell growth, proliferation, differentiation, and apoptosis. 4-HNE and metabolic products of other antioxidants (carotenoids) resemble each other in chemical nature of the product and influence general pathways of signal transduction. Manifestation of 4-HNE toxicity under oxidative stress conditions is regarded as a link to many diseases whose pathogenesis is connected with modifications of proteins and nucleic acids.
引用
收藏
页码：1069 / 1087
页数：19
相关论文
共 50 条
  • [1] Role of 4-hydroxy-trans-2-nonenal in cell functions
    E. E. Dubinina
    V. A. Dadali
    [J]. Biochemistry (Moscow), 2010, 75 : 1069 - 1087
  • [2] Metabolism of 4-hydroxy-trans-2-nonenal: role of cytochrome P450
    Prough, RA
    West, MB
    Srivastava, S
    Bhatnagar, A
    [J]. FASEB JOURNAL, 2003, 17 (04): : A610 - A610
  • [3] Metabolism of 4-hydroxy-trans-2-nonenal in the ischemic heart: Role of aldose reductase
    Awe, SO
    Srivastava, S
    Kaiserova, K
    Bhatnagar, A
    [J]. FASEB JOURNAL, 2005, 19 (04): : A700 - A700
  • [4] Inhibition of Cardiac Myocyte Contraction by 4-Hydroxy-Trans-2-Nonenal
    Aberle II N.S.
    Picklo Sr. M.J.
    Amarnath V.
    Ren J.
    [J]. Cardiovascular Toxicology, 2004, 4 (1) : 21 - 28
  • [5] The metabolic fate of 4-hydroxy-trans-2-nonenal (HNE) in cardiac mitochondria
    Liu, SQ
    Srivastava, S
    Prough, R
    Bhatnagar, A
    [J]. FASEB JOURNAL, 2002, 16 (04): : A144 - A144
  • [6] Myocardial ischaemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal
    Hill, Bradford G.
    Awe, Sunday O.
    Vladykovskaya, Elena
    Ahmed, Yonis
    Liu, Si-Qi
    Bhatnagar, Aruni
    Srivastava, Sanjay
    [J]. BIOCHEMICAL JOURNAL, 2009, 417 : 513 - 524
  • [7] Different enantioselectivity of 4-hydroxy-trans-2-nonenal oxidation in rat brain and liver mitochondria
    Brichac, J
    Honzatko, A
    Picklo, MJ
    [J]. JOURNAL OF NEUROCHEMISTRY, 2005, 94 : 41 - 41
  • [8] Mass spectrometry for detection of 4-hydroxy-trans-2-nonenal (HNE) adducts with peptides and proteins
    Carini, M
    Aldini, G
    Facino, RM
    [J]. MASS SPECTROMETRY REVIEWS, 2004, 23 (04) : 281 - 305
  • [9] Observation of heavy atom effects in the development of water soluble caged 4-hydroxy-trans-2-nonenal
    Jones, Paul B.
    Brinson, Robert G.
    Sarma, Saurav J.
    Elkazaz, Salwa
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (22) : 4204 - 4211
  • [10] Metabolism of the lipid peroxidation product, 4-hydroxy-trans-2-nonenal, in isolated perfused rat heart
    Srivastava, S
    Chandra, A
    Wang, LF
    Seifert, WE
    DaGue, BB
    Ansari, NH
    Srivastava, SK
    Bhatnagar, A
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (18) : 10893 - 10900
12345