Synthesis and reactivity of 2-polyfluoroalkylchromene-4(4H)-thiones

被引：13

作者：

Usachev, BI ^{[1
]}

Shafeev, MA ^{[1
]}

Sosnovskikh, VY ^{[1
]}

机构：

[1] AM Gorky Ural State Univ, Ekaterinburg 620083, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2004年 / 53卷 / 10期

基金：

俄罗斯基础研究基金会;

关键词：

2-polyfluoroalkylchromene-4(4H)-thiones; amines; hydrazines; hydroxylamine; anils; chromone phenylhydrazones; chromone oximes; pyrazoles; isoxazolines;

D O I：

10.1007/s11172-005-0115-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Polyfluoroalkylchromene-4(4H)-thiones, synthesized from 2-polyfluoroalkylchromones and P2S5, react with aniline, phenylhydrazines, and hydroxylamine at the C(4) atom and afford corresponding anils, phenylhydrazones, and oximes of chromones. On heating in alcohol in the presence of concentrated HCl, chromone phenylhydrazones and oximes undergo ring closure to form 3-(2-hydroxyaryl)-1-phenyl-5-polyfluoroalkylpyrazoles and 5-hydroxy-3-(2-hydroxyaryl)-5-polyfluoroalkyl-Delta(2)-isoxazolines.

引用

页码：2285 / 2292

页数：8

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