MiR-219-5p Inhibits the Growth and Metastasis of Malignant Melanoma by Targeting BCL-2

被引：30

作者：

Long, Jianwen ^{[1
,2
,3
]}

Menggen, Qiqige ^{[4
]}

Wuren, Qimige ^{[4
]}

Shi, Quan ^{[2
,3
]}

Pi, Xianming ^{[2
,3
]}

机构：

[1] Hubei Univ Chinese Med, Sch Clin Med 1, Dept Dermatol, Wuhan, Hubei, Peoples R China

[2] Hubei Prov Hosp Tradit Chinese Med, Dept Dermatol, Wuhan, Peoples R China

[3] Hubei Prov Acad Tradit Chinese Med, Dept Dermatol, Wuhan, Hubei, Peoples R China

[4] Mongolian Med Hosp, Dept Dermatol, Bortala Mongol Autonomou, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2017年 / 2017卷

关键词：

CANCER; IMMUNOTHERAPY; EXPRESSION; MICRORNAS; INVASION; ROLES; CELLS;

D O I：

10.1155/2017/9032502

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Malignant melanoma is a very dangerous tumor which is resistant to conventional therapy. MicroRNA exerts a vital function in promoting or inhibiting tumor development. The research has investigated the expression and function of miR-219-5p inmelanoma. As a result, miR-219-5p expression was distinctly reduced inmelanoma tissues and cell lines and was negatively correlated with Bcl-2 protein level in melanoma. Patients with low miR-219-5p level represented obviously a low overall survival in comparison with patients with high miR-219-5p level. The upregulation of miR-219-5p inhibited melanoma growth and metastasis and strengthened melanoma cells chemosensitivity by targeting Bcl-2. Therefore, the modulation of miR-219-5p expression may be a novel treatment strategy in melanoma.

引用

页数：7

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