Cap-binding complex (CBC)

被引：131
|
作者：
Gonatopoulos-Pournatzis, Thomas [1 ]
Cowling, Victoria H. [1 ]
机构：
[1] Univ Dundee, Coll Life Sci, MRC, Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
来源：
BIOCHEMICAL JOURNAL | 2014年 / 457卷
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
cap-binding complex (CBC); 7-methylguanosine cap (7mG); splicing; transcription; translation; PRE-MESSENGER-RNA; TRANSLATION INITIATION-FACTOR; CARBOXYL-TERMINAL DOMAIN; NONSENSE-MEDIATED DECAY; POLYMERASE-II CTD; U-SNRNA EXPORT; CAPPING ENZYME; PROTEIN COMPLEX; TRANSCRIPTION ELONGATION; FISSION YEAST;
D O I：
10.1042/BJ20131214
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events throughout the lifetime of the transcript. One of the most important mediators of 7mG functions is CB C (cap-binding complex). CB C has a key role in several gene expression mechanisms, including transcription, splicing, transcript export and translation. Gene expression can be regulated by signalling pathways which influence CBC function. The aim of the present review is to discuss the mechanisms by which CBC mediates and co-ordinates multiple gene expression events.
引用
收藏
页码：231 / 242
页数：12
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