In vivo T-cell depletion with pretransplant low-dose antithymocyte globulin is associated with reduced transplant-related mortality and improved clinical outcome in patients receiving allogeneic hematopoietic stem cell transplantation from unrelated and partially matched related donors

被引：8
|
作者：
Busca, Alessandro [1 ]
Locatelli, Franco
Flonta, Simona Emilia
Ciccone, Gianni [2 ]
Baldi, Ileana [2 ]
D'Ardia, Stefano
Allione, Bernardino
Falda, Michele
机构：
[1] Osped San Giovanni Battista Torino, Stem Cell Transplant Ctr, AOU San Giovanni Battista, I-10126 Turin, Italy
[2] CPO Piemonte, AOU San Giovanni Battista, Canc Epidemiol Unit, Turin, Italy
来源：
AMERICAN JOURNAL OF HEMATOLOGY | 2011年 / 86卷 / 02期
关键词：
VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; INFECTIOUS COMPLICATIONS; PERIPHERAL-BLOOD; CHRONIC GRAFT; THYMOGLOBULIN; PROPHYLAXIS; RECIPIENTS; RISK; FLUDARABINE;
D O I：
10.1002/ajh.21907
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Graft versus host disease (GVHD) represents one of the major limiting factors to the successful applicability of hematopoietic stem cells transplantation (HSCT). In particular, allogeneic HSCT from alternative donors with unmanipulated graft results in an increased risk of both acute and chronic GVHD compared with matched sibling donor transplants [1]. At the present, none of the GVHD prophylactic strategies currently in use, including calcineurin inhibitors [2], T-lymphocyte depletion, and monoclonal antibodies [3,4], have been proven to be of superior efficacy over another.
引用
收藏
页码：214 / 217
页数：4
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