Evaluation of TLR4 expression and chosen parameters of oxidative-antioxidative balance in young children with food allergy

被引：2

作者：

Kamer, Barbara ^{[1
]}

Kulig, Karolina ^{[1
]}

Lewkowicz, Przemyslaw ^{[2
]}

Kamer-Bartosinska, Anna ^{[3
]}

Tchorzewski, Henryk ^{[2
]}

机构：

[1] Polish Mothers Mem Hosp, Res Inst, Dept Pediat & Allergol 2, PL-93338 Lodz, Poland

[2] Polish Mothers Mem Hosp, Res Inst, Dept Clin Immunol, PL-93338 Lodz, Poland

[3] Polish Mothers Mem Hosp, Res Inst, Surg Gynecol Dept, PL-93338 Lodz, Poland

来源：

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA | 2010年 / 48卷 / 03期

关键词：

allergy; young children; TLR4; receptor; chemiluminescence; TAS; oxidative-antioxidative balance; TOLL-LIKE-RECEPTORS; NEUTROPHIL; CELLS; CHALLENGE; EOSINOPHILS; METABOLISM; MICROBES; INFANTS;

D O I：

10.2478/v10042-010-0068-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The authors evaluated mRNA TLR4 expression on neutrophils and the chosen parameters of oxidative-antioxidative balance in blood of 35 children with food allergy (17 of them with IgE-dependent allergy and 18 with IgE-independent allergy) and 15 healthy children without any allergy. The age of these children ranged from 1 to 36 months. Children with food allergy in comparison with healthy children were found to have lower mRNA TLR4 expression, higher average value of chemiluminescence (CL) and its increase after stimulation by fMLP, PMA and OZ as well as lower TAS values. Disturbances of oxidative-antioxidative balance were found in children with food allergy. We suggest that natural immunity is involved in the development of food allergy mechanisms. Moreover, chemiluminescence can be used as an additional diagnostic test.

引用

页码：346 / 350

页数：5