Microparticle surface layering through dry coating: impact of moisture content and process parameters on the properties of orally disintegrating tablets

被引：1

作者：

Alyami, Hamad ^{[1
]}

Koner, Jasdip ^{[1
]}

Dahmash, Eman Z. ^{[1
]}

Bowen, James ^{[2
]}

Terry, David ^{[1
,3
]}

Mohammed, Afzal R. ^{[1
]}

机构：

[1] Aston Univ, Aston Sch Pharm, Birmingham B4 7ET, W Midlands, England

[2] Open Univ, Dept Engn & Innovat, Milton Keynes, Bucks, England

[3] Children Hosp, Birmingham, W Midlands, England

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 2017年 / 69卷 / 07期

关键词：

composite; disintegration; flowability; hardness; nano-indentation; PHARMACEUTICAL POWDERS; FLOWABILITY; COMPRESSION; COMPACTION; EXCIPIENTS; FLOW;

D O I：

10.1111/jphp.12623

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

ObjectivesThe aim of this study was to investigate the influence of process parameters during dry coating on particle and dosage form properties upon varying the surface adsorbed moisture of microcrystalline cellulose (MCC), a model filler/binder for orally disintegrating tablets (ODTs). MethodsThe moisture content of MCC was optimised using the spray water method and analysed using thermogravimetric analysis. Microproperty/macroproperty assessment was investigated using atomic force microscopy, nano-indentation, scanning electron microscopy, tablet hardness and disintegration testing. Key findingsThe results showed that MCC demonstrated its best flowability at a moisture content of 11.2% w/w when compared to control, comprising of 3.9% w/w moisture. The use of the composite powder coating process (without air) resulted in up to 80% increase in tablet hardness, when compared to the control. The study also demonstrated that surface adsorbed moisture can be displaced upon addition of excipients during dry processing circumventing the need for particle drying before tabletting. ConclusionsIt was concluded that MCC with a moisture content of 11% w/w provides a good balance between powder flowability and favourable ODT characteristics.

引用

页码：807 / 822

页数：16