Alternatives to animal experimentation in parasitology

被引:12
|
作者
Eckert, J
机构
关键词
alternative methods; legislation; guidelines; cryopreservation; in vitro culture; chick embryo; artificial feeding;
D O I
10.1016/S0304-4017(97)00027-7
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
In parasitology, several measures can contribute to the aims of 3R (Reduction, Refinement and Replacement of animal experimentation). These include legal regulations, international guidelines for evaluating antiparasitic drugs, the refinement of animal models for parasitic infections, cryopreservation and cultivation of parasites in vitro or in chicken eggs, the maintenance of arthropods by artificial feeding, and the use of immunological and molecular in vitro techniques (e.g. the production of recombinant antigens for vaccines). Considerable progress has been achieved in the development of alternative techniques but both their standardisation and validation are not far advanced. A wider acceptance and use of alternative methods will only be achieved if research can offer economic alternatives that are as effective and reliable as animal experiments. Great efforts are needed for further progress. (C) 1997 Elsevier Science B.V.
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页码:99 / 120
页数:22
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