A new 1,2,3-triazolo[1,2]benzodiazepine ring system

被引：3
|
作者：
Knight, DW
Little, PB
机构：
[1] Department of Chemistry, Cardiff University, Cardiff CF1 3TB
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 28期
关键词：
D O I：
10.1016/S0040-4039(97)01064-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Dianion 2 derived from N-Boc-aminobenzotriazole 1 condenses in a [1.2]-fashion with alpha,beta-unsaturated aldehydes; subsequent oxidation of the resulting allylic alcohols 7 using manganese(IV) oxide or, less effectively, treatment of the derived acetates 10 with Pd(0), results in direct formation of the novel triazolo[1,2]benzodiazepines 9 and 11 by intramolecular addition of the pendant amino group. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：5037 / 5040
页数：4
相关论文
共 50 条
  • [1] 1,2,3-triazolo[1,5-a][1,4]- and 1,2,3-triazolo[1,5-a][1,5]benzodiazepine derivatives: synthesis and benzodiazepine receptor binding
    Bertelli, L
    Biagi, G
    Giorgi, I
    Livi, O
    Manera, C
    Scartoni, V
    Martini, C
    Giannaccini, G
    Trincavelli, L
    Barili, PL
    [J]. FARMACO, 1998, 53 (04): : 305 - 311
  • [2] 1,2,3-Triazolo[1,5-a][1,3]benzodiazepine a new heterocyclic system: Synthesis, benzodiazepine receptor binding and theoretical calculations
    Biagi, G
    Giorgi, I
    Livi, O
    Scartoni, V
    Velo, S
    DeSantis, B
    Martinelli, A
    Martini, C
    Senatore, G
    [J]. FARMACO, 1996, 51 (01): : 13 - 18
  • [3] Synthesis of New 1,2,3-Triazolo[1,5-a]quinazolinones
    Pokhodylo, Nazariy T.
    Matiychuk, Vasyl S.
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 47 (02) : 415 - 420
  • [4] 1,2,3-triazolo[1,5-a]quinoxalines: synthesis and binding to benzodiazepine and adenosine receptors
    Bertelli, L
    Biagi, G
    Giorgi, I
    Manera, C
    Livi, O
    Scartoni, V
    Betti, L
    Giannaccini, G
    Trincavelli, L
    Barili, PL
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1998, 33 (02) : 113 - 122
  • [5] New 1,2,3-triazolo[1,5-a]quinoxalines: synthesis and binding to benzodiazepine and adenosine receptors. II
    Biagi, G
    Giorgi, I
    Livi, O
    Scartoni, V
    Betti, L
    Giannacini, G
    Trincavelli, ML
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (07) : 565 - 571
  • [6] 1,2,3-triazolo[1,5-a]quinazolines: Synthesis, benzodiazepine receptor binding and theoretical calculations
    Biagi, G
    Giorgi, I
    Livi, O
    Scartoni, V
    Velo, S
    Lucacchini, A
    Senatore, G
    DeSantis, B
    Martinelli, A
    [J]. FARMACO, 1996, 51 (02): : 131 - 136
  • [7] Substituted 1,2,3-triazolo[1,5-a]quinazolines: synthesis and binding to benzodiazepine and adenosine receptors
    Bertelli, L
    Biagi, G
    Giorgi, I
    Livi, O
    Manera, C
    Scartoni, V
    Lucacchini, A
    Giannaccini, G
    Barili, PL
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (03) : 333 - 341
  • [8] HETEROPENTALENES - ON 5H-PYRAZOLO[1',2'-1,2]-1,2,3-TRIAZOLO[5,4-A]-PHENAZINYLIUMIDE
    ALBINI, A
    BETTINETTI, GF
    MINOLI, G
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1981, (07): : 1821 - 1825
  • [9] SYNTHESIS OF 1,2,3-TRIAZOLO[1,5-A]-1,3,5-TRIAZINE - NEW HETEROCYCLIC SYSTEM
    KLEIN, RS
    DELASHERAS, FG
    TAM, SYK
    WEMPEN, I
    FOX, JJ
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1976, 13 (03) : 589 - 592
  • [10] SYNTHESIS OF 1,2,3-TRIAZOLO [1,5-A]QUINOXALINIUM AND 1,2,3-TRIAZOLO[5,1-C]-BENZO-1,2,4-TRIAZINIUM SALTS
    MESSMER, A
    SZIMAN, O
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1965, 4 (12) : 1074 - &
12345