Emerging In Vitro 3D Tumour Models in Nanoparticle-Based Gene and Drug Therapy

被引：3

作者：

Wong, Joanna K. ^{[1
]}

Seifalian, Amelia ^{[2
]}

Mohseni, Rashin ^{[3
]}

Hamidieh, Amir Ali ^{[3
]}

MacLaren, Robert E. ^{[4
]}

Habib, Nagy ^{[5
]}

Seifalian, Alexander M. ^{[6
]}

机构：

[1] Imperial Coll London, Sch Med, London, England

[2] UCL, Sch Med, London, England

[3] Univ Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Ctr, Tehran, Iran

[4] Univ Oxford, Dept Clin Neurosci, Nuffield Lab Ophthalmol, Oxford, England

[5] Imperial Coll London, Fac Med, Dept Surg & Canc, London, England

[6] Nanotechnol & Regenerat Med Ctr Ltd, London BioSci Innovat Ctr, London, England

来源：

TRENDS IN BIOTECHNOLOGY | 2018年 / 36卷 / 05期

关键词：

D O I：

10.1016/j.tibtech.2018.02.002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

3D models are emerging as valuable tools for personalised nanoparticle-based cancer treatments. 3D models represent in vivo cancers more realistically than 2D patterns that are grown in Petri dishes. However, creating a 3D cancer model that mimics the complexity and heterogeneity of cancers in vivo remains difficult.

引用

页码：477 / 480

页数：5

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