Clinical Implications of Caveolins in Malignancy and Their Potential as Therapeutic Targets

被引：5
|
作者：
Tamaskar, Ila [1 ]
Zhou, Ming [1 ]
机构：
[1] Cleveland Clin, Taussig Canc Ctr, Dept Expt Therapeut, Cleveland, OH 44195 USA
来源：
CURRENT ONCOLOGY REPORTS | 2008年 / 10卷 / 02期
关键词：
Prostate Cancer; Radical Prostatectomy; Small Cell Lung Cancer; Transitional Cell Carcinoma; Renal Oncocytoma;
D O I：
10.1007/s11912-008-0017-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Caveolae are cell membrane invaginations that were first described in the early 1950s. Since then, researchers have undertaken numerous studies to define their role in normal physiology and disease. The caveolin proteins, particularly caveolin-1, are the major structural and functional components of caveolae, which are involved in a plethora of cellular functions. This review briefly describes the role of caveolae and caveolin proteins in these cellular processes and in different types of human cancers. In addition, it also discusses the use of caveolin-1 as a potential diagnostic and prognostic marker and therapeutic target.
引用
收藏
页码：101 / 106
页数：6
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