Mouse and Human Spermatogonial Stem Cells

被引：0

作者：

Koruji, Morteza ^{[1
]}

Azizi, Hossein ^{[2
,3
]}

Shahverdi, Abdolhossein ^{[2
,3
]}

Baharvand, Hossein ^{[2
,3
,4
]}

机构：

[1] Iran Univ Med Sci, Dept Anat Sci, Sch Med, Tehran, Iran

[2] ACECR, Royan Inst Stem Cell Biol & Technol, Dept Stem Cells & Dev Biol, Tehran, Iran

[3] ACECR, Dept Embryol, Royan Inst Reprod Biomed, Tehran, Iran

[4] Univ Sci & Culture, Dept Dev Biol, ACECR, Tehran, Iran

来源：

YAKHTEH | 2010年 / 12卷 / 02期

关键词：

Spermatogonia; Stem Cells; Identification; Isolation; Culture; VITAMIN-A-DEFICIENT; LONG-TERM CULTURE; IN-VITRO; GERM-CELLS; UNDIFFERENTIATED SPERMATOGONIA; GROWTH-FACTORS; C-KIT; FUNCTIONAL-CHARACTERISTICS; DIFFERENTIAL EXPRESSION; SEMINIFEROUS EPITHELIUM;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Spermatogonial stem cells (SSCs) are in the beginning of a complex process in which they transmit genetic information from generation to generation. Any failure in this process can result in infertility. It has been suggested that transplantation of spermatogonial stem cells, following their maintenance and culturing, may restore fertility in some infertile patients. Because fertility restoration through SSCs transplantation has been successfully achieved in animal experiments, we hope human studies can follow in the near future. The isolation and cultivation of SSCs help us study their biological characteristics and their application in therapeutic approaches. In this review, we studied spermatogenesis in rodents and humans. We also compared markers and different SSC culture systems in both.

引用

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页码：147 / 158

页数：12

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