suPAR and chronic kidney disease-a podocyte story

被引：38

作者：

Zeier, Martin ^{[1
]}

Reiser, Jochen ^{[2
]}

机构：

[1] Heidelberg Univ, Div Nephrol, Heidelberg, Germany

[2] Rush Univ, Med Ctr, Dept Med, Kellogg Bldg,Suite 1003, Chicago, IL 60612 USA

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2017年 / 469卷 / 7-8期

关键词：

suPAR; Integrin; Podocyte; FSGS; CKD; PLASMINOGEN-ACTIVATOR RECEPTOR; SOLUBLE UROKINASE RECEPTOR; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; CIRCULATING SUPAR; GLOMERULAR-FILTRATION; PROTEINURIA; PROGRESSION; DIET;

D O I：

10.1007/s00424-017-2026-7

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The soluble urokinase-type plasminogen activator receptor (suPAR) is a circulating signaling molecule derived from immature myeloid cells. Elevated levels of suPAR have been linked to the pathogenesis of the kidney disease focal and segmental glomerulosclerosis. Here, suPAR acts on podocytes by activating alpha v beta 3 integrins. Large observational studies showed that suPAR also predicts chronic kidney disease incidence and progression by predating the disease by several years prior to any other known marker of renal dysfunction. suPAR is rapidly developing into a prime target for pharmacotherapy as its neutralization is forecasted to be feasible and safe.

引用

页码：1017 / 1020

页数：4

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