Ovarian stimulation in polycystic ovary syndrome patients: the role of body mass index

被引：18
|
作者：
Orvieto, Raoul [1 ,2 ]
Nahum, Ravit [1 ,2 ]
Meltcer, Simion [1 ,2 ]
Homburg, Roy [1 ,2 ]
Rabinson, Jacob [1 ,2 ]
Anteby, Eyal Y. [1 ,2 ]
Ashkenazi, Jacob [3 ,4 ]
机构：
[1] Barzilai Govt Hosp, Dept Obstet & Gynecol, Ashqelon, Israel
[2] Ben Gurion Univ Negev, Sch Med, Beer Sheva, Israel
[3] Helen Schneider Hosp Women, Dept Obstet & Gynecol, Rabin Med Ctr, Petah Tiqwa, Israel
[4] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
来源：
REPRODUCTIVE BIOMEDICINE ONLINE | 2009年 / 18卷 / 03期
关键词：
body mass index; GnRH agonist; GnRH antagonist; IVF outcome; PCOS; pregnancy; IN-VITRO FERTILIZATION; FINAL FOLLICULAR MATURATION; LUTEINIZING-HORMONE; EMBRYO-TRANSFER; ADVERSELY AFFECT; GNRH AGONIST; OBESE WOMEN; HYPERSTIMULATION; GONADOTROPIN; INFERTILITY;
D O I：
10.1016/S1472-6483(10)60090-9
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
In all attempt to examine whether body mass index (BMI) may influence IVF outcome in polycystic ovary syndrome (PCOS) patients undergoing ovarian stimulation with either gonadotrophin-releasing hormone (GnRH)-agonist (agonist group) or antagonist (antagonist group), 100 IVF cycles were studied: 35 in the agonist and 65 in the antagonist groups. In both agonist and antagonist groups, patients with BMI <= 25 kg/m(2) had a significantly higher fertilization rate compared with patients with BMI > 25 kg/m(2) (P < 0.02 and P < 0.01, respectively). Lean patients (BMI <= 25) undergoing ovarian Stimulation using the GnRH-agonist, demonstrated the highest pregnancy rate. In conclusion, in this series of PCOS patients undergoing IVF-embryo transfer cycles, ovarian stimulation utilizing the midluteal long GnRH-agonist suppressive protocol yielded a higher pregnancy rate in lean patients, probably due to its ability to lower the high basal LH milieu and its detrimental effect on oocyte quality and implantation potential.
引用
收藏
页码：333 / 336
页数：4
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