Metabolic engineering for the microbial production of marine bioactive compounds

被引：27
|
作者：
Mao, Xiangzhao [1 ,2 ]
Liu, Zhen [2 ]
Sun, Jianan [2 ]
Lee, Sang Yup [1 ]
机构：
[1] Korea Adv Inst Sci & Technol, Inst BioCentuty, Ctr Syst & Synthet Biotechnol,Metab & Biomol Engn, Dept Chem & Biomol Engn,Plus Program BK21,BioProc, Daejeon, South Korea
[2] Ocean Univ China, Coll Food Sci & Engn, Qingdao, Peoples R China
来源：
BIOTECHNOLOGY ADVANCES | 2017年 / 35卷 / 08期
基金：
美国国家科学基金会; 新加坡国家研究基金会;
关键词：
Marine bioactive compounds; Metabolic engineering; Terpenoids; Omega-3 polyunsaturated fatty acids; Marine natural drugs; Squalene; Astaxanthin; Docosahexaenoic acid; Eicosapentaenoic acid; POLYUNSATURATED FATTY-ACIDS; BIOSYNTHESIS GENE-CLUSTER; IMPROVE ASTAXANTHIN PRODUCTION; BETA-CAROTENE HYDROXYLASE; BACTERIUM METHYLOMONAS SP; EICOSAPENTAENOIC ACID; ESCHERICHIA-COLI; HETEROLOGOUS EXPRESSION; SACCHAROMYCES-CEREVISIAE; HAEMATOCOCCUS-PLUVIALIS;
D O I：
10.1016/j.biotechadv.2017.03.001
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Many marine bioactive compounds have medicinal and nutritional values. These bioactive compounds have been prepared using solvent-based extraction from marine bio-resources or chemical synthesis, which are costly, inefficient with low yields, and environmentally unfriendly. Recent advances in metabolic engineering allowed to some extent more efficient production of these compounds, showing promises to meet the increasing demand of marine natural bioactive compounds. In this paper, we review the strategies and statuses of metabolic engineering applied to microbial production of marine natural bioactive compounds including terpenoids and their derivatives, omega-3 polyunsaturated fatty acids, and marine natural drugs, and provide perspectives. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码：1004 / 1021
页数：18
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