The Future of Human Health Risk Assessment of Environmental Chemicals

被引:2
|
作者
Hodgson, Ernest [1 ]
机构
[1] N Carolina State Univ, Dept Environm & Mol Toxicol, Raleigh, NC 27695 USA
来源
关键词
CHLORPYRIFOS; MODELS;
D O I
10.1016/B978-0-12-415813-9.00011-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dramatic changes are beginning to take place in risk assessment, changes that will involve rapid, high-throughput assays capable of analyzing large numbers of samples in a short time. These new systems will incorporate many of the aspects of cellular and molecular biology, including human and human-derived cell lines, toxicogenomics, proteomics, and metabolomics. The large amount of data generated will require a systems biology approach if it is to be reduced to generalizations of value in risk management. The current chapter briefly describes the emerging systems and their component parts.
引用
收藏
页码:307 / 322
页数:16
相关论文
共 50 条
  • [1] Prioritising environmental chemicals for human health risk assessment
    Hughes, J
    Courage, C
    Capleton, A
    Duarte-Davidson, R
    TOXICOLOGY, 2001, 168 (01) : 73 - 73
  • [2] Application of OMICS data to human health risk assessment of environmental chemicals
    Ge, Yue
    Bruno, Maribel
    Preston, Julian
    Ross, Jeffrey
    TOXICOLOGY LETTERS, 2009, 189 : S40 - S40
  • [3] Prospects for incorporation of epigenetic biomarkers in human health and environmental risk assessment of chemicals
    Jeremias, Guilherme
    Goncalves, Fernando J. M.
    Pereira, Joana L.
    Asselman, Jana
    BIOLOGICAL REVIEWS, 2020, 95 (03) : 822 - 846
  • [4] AOP strategy: shaping the future for human health and environmental risk assessment
    Whelan, Maurice
    TOXICOLOGY LETTERS, 2014, 229 : S10 - S10
  • [5] RISK ASSESSMENT OF ENVIRONMENTAL CHEMICALS
    FAN, A
    HOWD, R
    DAVIS, B
    ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1995, 35 : 341 - 368
  • [6] RISK ASSESSMENT OF ENVIRONMENTAL CHEMICALS
    MERIAN, E
    CHEMOSPHERE, 1978, 7 (04) : 307 - 313
  • [7] Environmental and human health risk assessment
    Lahaniatis, MR
    Pakalin, S
    Kettrup, A
    FRESENIUS ENVIRONMENTAL BULLETIN, 2002, 11 (10A): : 713 - 735
  • [8] Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals
    Bourdon-Lacombe, Julie A.
    Moffat, Ivy D.
    Deveau, Michelle
    Husain, Mainul
    Auerbach, Scott
    Krewski, Daniel
    Thomas, Russell S.
    Bushel, Pierre R.
    Williams, Andrew
    Yauk, Carole L.
    REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2015, 72 (02) : 292 - 309
  • [9] Approaches to advancing quantitative human health risk assessment of environmental chemicals in the post-genomic era
    Chiu, Weihsueh A.
    Euling, Susan Y.
    Scott, Cheryl Siegel
    Subramaniam, Ravi P.
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2013, 271 (03) : 309 - 323
  • [10] Environmental risk assessment of existing chemicals
    Ahlers, J.
    Diderich, R.
    Klaschka, U.
    Marschner, A.
    Schwarz-Schulz, B.
    Environmental Science and Pollution Research, 1994, 1 (02) : 117 - 123