Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis

被引：62
|
作者：
Cheng, Hao [1 ,2 ,3 ]
Long, Feiwu [1 ,2 ,3 ]
Jaiswar, Mukesh [1 ,2 ,3 ]
Yang, Lie [1 ,2 ,3 ]
Wang, Cun [1 ,2 ,3 ]
Zhou, Zongguang [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Gastrointestinal Surg, Chengdu 610041, Sichuan Provinc, Peoples R China
[2] Sichuan Univ, West China Hosp, Inst Digest Surg, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China
来源：
SCIENTIFIC REPORTS | 2015年 / 5卷
关键词：
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ELEVATED PREOPERATIVE NEUTROPHIL; SYSTEMIC INFLAMMATION; BLADDER-CANCER; SURVIVAL; MARKERS;
D O I：
10.1038/srep11026
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The relationship between the neutrophil-to-lymphocyte ratio (NLR) and tumours as a prognostic factor has been reported in many studies. In this meta-analysis, we evaluated the prognostic role of the NLR in pancreatic cancer (PC). A systematic search was performed in PubMed and Embase for relevant studies. Data from and characteristics of each study were extracted. A meta-analysis was performed to analyse the prognostic role of the NLR using the hazard ratio (HR) and 95% confidence intervals (95% CI). As a result, a total of 2035 patients in 9 cohorts were included in this meta-analysis. The pooled HR of 1.587 (95% CI: 1.411-1.785, p < 0.01) showed that patients with an elevated NLR were expected to have shorter overall survival (OS) after treatment. This meta-analysis suggests that an elevated NLR can be used as a predictor of survival in patients with pancreatic cancer.
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页数：7
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