Plasma tumour necrosis factor-α and early carotid atherosclerosis in healthy middle-aged men

被引:233
|
作者
Skoog, T [1 ]
Dichtl, W
Boquist, S
Skoglund-Andersson, C
Karpe, F
Tang, R
Bond, MG
de Faire, U
Nilsson, J
Eriksson, P
Hamsten, A
机构
[1] Karolinska Hosp, King Gustaf V Res Inst, Atherosclerosis Res Unit, S-17176 Stockholm, Sweden
[2] Karolinska Hosp, Dept Cardiol, S-17176 Stockholm, Sweden
[3] Karolinska Hosp, Dept Med, Cardiovasc Lab, S-17176 Stockholm, Sweden
[4] Karolinska Inst, Inst Environm Med, Div Cardiovasc Epidemiol, S-10401 Stockholm, Sweden
[5] Lund Univ, Malmo Univ Hosp, Dept Med, Wallenberg Lab, Malmo, Sweden
[6] Wake Forest Univ, Bowman Gray Sch Med, Div Ultrasound Res, Winston Salem, NC USA
关键词
atherosclerosis; common carotid intima-media thickness; tumour necrosis factor-alpha; intercellular adhesion molecule-1; vascular adhesion molecule-1; E-selectin;
D O I
10.1053/euhj.2001.2805
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, which is implicated in some metabolic disorders and may play a role in the development of cardiovascular disease. We examined whether plasma TNF-alpha is related to established cardiovascular risk indicators, plasma levels of soluble cellular adhesion molecules and carotid artery intima-media thickness determined by ultrasound examination in a population-based cohort of 96 healthy 50-year-old men. Methods and Results TNF-alpha and cellular adhesion molecules were measured with enzyme-linked immunosorbent assays. Plasma TNF-alpha concentration was associated with systolic and diastolic blood pressure, degrees of alimentary lipaemia, plasma very low density lipoprotein triglyceride, low density lipoprotein (LDL) cholesterol concentrations and peak LDL particle size. Two indices of insulin resistance as well as all soluble cellular adhesion molecules correlated positively with TNF-alpha. The plasma TNF-alpha concentration was associated with common carotid intima-media thickness in univariate analysis. In contrast, soluble E-selectin and postprandial triglycerides, but not TNF-alpha, were independent determinants of common carotid intima-media thickness. Conclusion The plasma TNF-alpha concentration is associated with degrees of early atherosclerosis and correlates with metabolic and cellular perturbations that are considered important for the vascular process. (Eur Heart J, 2002; 23: 376-383, doi:10.1053/euhj.2001. (C) 2001 The European Society of Cardiology.
引用
收藏
页码:376 / 383
页数:8
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